| Titre : | Glucose and insulin components of the metabolic syndrome are associated with hyperandrogenism in postmenopausal women : The atherosclerosis risk in communities study. (2004) |
| Auteurs : | Sherita-Hill GOLDEN ; Adrian DOBS ; Bruce-B DUNCAN ; . JINGZHONG DING ; Maria-Ines SCHMIDT ; Moyses Szklo ; Federal University of Rio Grande do Sul. School of Medicine. Graduate Studies Program in Epidemiology. Porto Alegre. BRA ; Johns Hopkins University School of Medicine. Department of Medicine. Baltimore. MD. USA |
| Type de document : | Article |
| Dans : | American journal of epidemiology (vol. 160, n° 6, 2004) |
| Pagination : | 540-548 |
| Langues: | Anglais |
| Mots-clés : | Glucose ; Insuline ; Association ; Homme ; Femme ; Ménopause ; Produit substitution ; Epidémiologie ; Appareil circulatoire [pathologie] ; Glande endocrine [pathologie] ; Métabolisme [pathologie] ; Vaisseau sanguin [pathologie] |
| Résumé : | [BDSP. Notice produite par INIST-CNRS RGfR0x6h. Diffusion soumise à autorisation]. In 1990-1992, the authors investigated the association of total and free testosterone with the metabolic syndrome in postmenopausal US women not taking hormone replacement therapy (n=362) in a prevalent case-control study of carotid atherosclerosis. Free testosterone was estimated by using the free androgen index (FAI) (total testosterone/sex hormone-binding globulin ratio). The metabolic syndrome was defined as the presence of three or more of the following criteria : waist circumference>=35 inches (88.9 cm), triglycerides>=150 mg/dl, high density lipoprotein cholesterol<40 mg/dl, blood pressure>130/80 mmHg, fasting insulin>100 pmol/liter, or impaired glucose homeostasis (fasting glucose>=110 mg/dl or diagnosed diabetes mellitus). FAI, but not total testosterone, was strongly associated with the metabolic syndrome. Compared with women in the lowest FAI quartile, those in the highest quartile had a fivefold greater odds of having the metabolic syndrome (odds ratio=5.38,95% confidence interval : 2.70,10.7) after adjustment for age, race, and carotid atherosclerosis status. In multivariate analyses, the three-component metabolic syndrome combinations that contained both hyperinsulinemia and hyperglycemia were most strongly associated with increased FAI (absolute increase=0.41-0.54 compared with that for women who did not have these combinations ; all p's<0.001). Higher FAI was associated with the hyperinsulinemia and hyperglycemia components of the metabolic syndrome. The role of androgens in glucose homeostasis in postmenopausal women requires further study. |
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