| Titre : | Relation of contraceptive and reproductive history to ovarian cancer risk in carriers and noncarriers of BRCA1 gene mutations. (2004) |
| Auteurs : | V. MCGUIRE ; R. DICIOCCIO ; A. FELBERG ; E.M. JOHN ; M. MILLS ; K.L. OSTROW ; D.W. WEST ; A.S. WHITTEMORE ; Roswell Park Cancer Institute. Department of Cancer Genetics. Buffalo. NY. USA ; Stanford University School of Medicine. Departments of Health Research and Policy and Medicine. Stanford. CA. USA |
| Type de document : | Article |
| Dans : | American journal of epidemiology (vol. 160, n° 7, 2004) |
| Pagination : | 613-618 |
| Langues: | Anglais |
| Mots-clés : | Cancer ; Contraceptif oral ; Contraceptif ; Reproduction ; Facteur risque ; Génétique ; Voie orale ; Parité ; Stérilisation génitale ; Homme ; Epidémiologie ; Femme ; Stérilisation |
| Résumé : | [BDSP. Notice produite par INIST-CNRS R0xdUggr. Diffusion soumise à autorisation]. In the general population, ovarian cancer risk is inversely associated with oral contraceptive use, tubal ligation, and childbearing. Among carriers of BRCA1 gene mutations, the data are conflicting. The authors identified women diagnosed with incident invasive epithelial ovarian cancer in the San Francisco Bay Area of California from March 1997 through July 2001. They compared the contraceptive and reproductive histories of 36 carrier cases and 381 non carrier cases with those of 568 controls identified by random digit dialing who were frequency matched to cases on age and race/ethnicity. In both carriers and non carriers, reduced risk was associated with ever use of oral contraceptives (odds ratio=0.54 (95% confidence interval (CI) : 0.26,1.13) for carriers and 0.55 (95% CI : 0.41,0.73) for non carriers), duration of oral contraceptive use (risk reduction per year=13% (p=0.01) for carriers and 6% (p<0.001) for non carriers), history of tubal ligation (odds ratio=0.68 (95% CI : 0.25,1.90) for carriers and 0.65 (95% CI : 0.45,0.95) for non carriers), and increasing parity (risk reduction per childbirth=16% (p=0.26) for carriers and 24% (p<0.001) for non carriers). These data suggest that BRCA1 mutation carriers and non carriers have similar risk reductions associated with oral contraceptive use, tubal ligation, and parity. |
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