| Titre : | Tubal sterilization and risk of ovarian, endometrial and cervical cancer. A Danish population-based follow-up study of more than 65 000 sterilized women. Commentary. (2004) |
| Auteurs : | Susanne-K KJAER ; Louise-A BRINTON ; Gloria GRIDLEY ; Christoffer JOHANSEN ; Lene MELLEMKJAER ; Jorgen-H OLSEN ; David-M PURDIE |
| Type de document : | Article |
| Dans : | International journal of epidemiology (vol. 33, n° 3, 2004) |
| Pagination : | 596-604 |
| Langues: | Anglais |
| Mots-clés : | Facteur risque ; Epidémiologie ; Ligature trompes ; Trompe Fallope ; Danemark ; Europe ; Cancérologie ; Adulte ; Stérilisation génitale ; Homme ; Utérus [pathologie] ; Cancer ; Chirurgie |
| Résumé : | [BDSP. Notice produite par INIST-CNRS dR0x371Q. Diffusion soumise à autorisation]. Background : On the basis of a population-based cohort, we assessed the cancer risk, focusing on gynaecological cancers and pre-malignant lesions, among women with a previous tubal sterilization. Methods : Using the Danish Hospital Discharge Register we identified 65 232 women who had a tubal sterilization (1977-1993). The cohort was followed for cancer occurrence, and compared with the expected number based on the national cancer incidence rates. Results : The overall risk of ovarian cancer was decreased (standardized incidence ratio [SIR]=0.82 ; 95% CI : 0.6,1.0), and it was still decreased>=10 years after the sterilization (SIR=0.65 ; 95% CI : 0.4,1.0). The rate of endometrial cancer was also decreased (SIR=0.66 ; 95% CI : 0.5,1.0), the risk continued being moderately reduced during follow-up, although it was not statistically significant. Conclusions : In this nationwide, population-based study we find that women with tubal sterilization have a decreased risk of subsequent development of ovarian cancer. As the protective effect is not decreasing with years of follow-up, our data do not support that'screening'bias can explain the protective effect, but indicate that the sterilization itself may convey a reduction in risk. The same pattern is found for endometrial cancer, the association being less strong. |
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