| Titre : | Risk factors for breast cancer in elderly women. (2004) |
| Auteurs : | SWEENEY (Carol) : USA. University of Utah. Salt Lake City. UT. ; Kristin-E ANDERSON ; Cindy-K BLAIR ; Aaron-R FOLSOM ; Deann LAZOVICH ; University of Minnesota. Minneapolis. MN. USA |
| Type de document : | Article |
| Dans : | American journal of epidemiology (vol. 160, n° 9, 2004) |
| Pagination : | 868-875 |
| Langues: | Anglais |
| Mots-clés : | Cancer ; Facteur risque ; Sein ; Personne âgée ; Homme ; Femme ; Age ; Epidémiologie ; Glande mammaire [pathologie] |
| Résumé : | [BDSP. Notice produite par INIST-CNRS 2uC3iR0x. Diffusion soumise à autorisation]. As the population ages, an increasing fraction of women diagnosed with breast cancer will be elderly. Heterogeneity of breast cancer risk factors between pre-and postmenopausal women is recognized, but few studies have examined elderly women specifically. The authors describe the age-specific influence of risk factors for postmenopausal breast cancer, with emphasis on women aged 75 or more years. Among 36,658 members of the Iowa Women's Health Study (1986-2001), a population-based cohort study, 428 incident breast cancers were diagnosed in women aged 55-64 years, 1,297 in women aged 65-74 years, and 561 in women aged 75-84 years. Women with a body mass index (weight (kg)/height (m) (2)) in the highest versus the lowest quartile were at increased risk of breast cancer at age 75 or more years (adjusted hazard ratio=1.44,95% confidence interval (CI) : 1.12,1.84). Family history of breast cancer (hazard ratio=1.54,95% CI : 1.24,1.93 for a first-degree family history vs. none) and an older age at menopause (p (trend)=0.07) conferred increased risk for women aged 75 or more years, and a high number of live births was protective (hazard ratio=0.67,95% CI : 0.51,0.88 for five or more births compared with one or two). Obesity, a modifiable risk factor, remained positively associated with breast cancer for all age groups of postmenopausal women. |
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