| Titre : | CYP1A1, cigarette smoking, and colon and rectal cancer. (2004) |
| Auteurs : | Martha-L SLATTERY ; T.R. Levin ; K. MA ; M. MURTAUGH ; S. NEUHAUSEN ; W. SAMOWTIZ ; C. SWEENEY ; University of Utah Health Sciences Center. Health Research Center. Salt Lake City. UT. USA |
| Type de document : | Article |
| Dans : | American journal of epidemiology (vol. 160, n° 9, 2004) |
| Pagination : | 842-852 |
| Langues: | Anglais |
| Mots-clés : | Tabagisme ; Enzyme ; Protéine ; Tabac ; Epidémiologie ; Homme ; Hérédité ; Appareil digestif [pathologie] ; Intestin [pathologie] ; Cancer |
| Résumé : | [BDSP. Notice produite par INIST-CNRS 4drR0xsf. Diffusion soumise à autorisation]. Cytochrome P-450 (CYP) is involved in the activation and metabolism of polycyclic aromatic hydrocarbons in tobacco products. The authors evaluated the association of two polymorphisms in the CYP1A1 gene - the non coding Msp I polymorphism in the 3'-untranslated region and the Ile462Val polymorphism in exon 7 - with colon and rectal cancer. The authors used data from two incident case-control studies of colon cancer (1,026 cases and 1,185 controls) and rectal cancer (820 cases and 1,036 controls) conducted in California and Utah (1991-2002). CYP1A1 genotype was not associated with colon or rectal cancer. Having GSTM1 present, a CYP1A1 variant allele, and the rapid-acetylator NAT2 imputed phenotype was associated with increased risk of colon cancer (odds ratio=1.7,95% confidence interval : 1.2,2.3). Among men, the greatest colon cancer risk was observed for having any CYP1A1 variant allele and currently smoking (odds ratio=2.5,95% confidence interval : 1.3,4.8 ; Wald chi (2) test : p<0.01). Assessment of GSTM1 and CYP1A1 and rectal cancer in men showed a twofold elevation in risk for more than 20 pack-years of smoking, except among those with GSTM1 present who had a variant CYP1A1 allele. These data support the association between smoking and colon and rectal cancer. Smoking may have a greater impact on colorectal cancer risk based on CYP1A1 genotype ; this might further be modified by GSTM1 for rectal cancer risk. |
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