Résumé :
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[BDSP. Notice produite par INIST-CNRS xuR0xGpx. Diffusion soumise à autorisation]. Background : Endothelial cell dysfunction may be related to an increase in cellular oxidative stress. Carotenoids and vitamins could have an antioxidant-mediated tempering influence on endothelial function and inflammation, thereby reducing the risk of atherosclerosis. Methods : We measured serum carotenoids, alpha-tocopherol and Vitamin C concentrations in 379 subjects sampled from the general population. High-sensitive C-reactive protein (CRP), fibrinogen (Fbg) and leukocytes were measured as markers of inflammation. Furthermore, soluble intercellular adhesion molecule-1 (sICAM-1) and flow-mediated vasodilation (FMD ; n=165) were measured as markers of endothelial function. Relationships between serum carotenoids and vitamins and markers of endothelial function and inflammation were analysed after adjustment for confounding. Results : In the total study group, lutein and lycopene were inversely related to sICAM-1 with regression-coefficients of - 0.38+/-0.19 (p=0.04) and - 0.16+/-0.08 (p=0.04) per 1 mumol/l, respectively. bêta-Carotene was inverse related to leukocytes (-0.23+/-0.07 ; p=0.007) and CRP (-1.09+/-0.30 ; p=0.0003) per 1 mumol/l. Vitamin C was inverse related to CRP (-01+/-0.005 ; p=0.04) per 1 mumol/l whereas alpha-tocopherol was positively related to CRP (0.03+/-0.01 ; p=0.02) per 1 mu/l. Zeaxanthin was inversely related to FMD (31.2+/-15.3 ; p=0.04) per 1 micromol/l. Conclusion : The inverse relations between carotenoids, Vitamin C and SICAM-1, CRP and leukocytes may help to explain the possible protective effect of carotenoids and Vitamin C on atherosclerosis through an influence on inflammatory processes and endothelial function.
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