| Titre : | Multiresistant non-fermentative Gram-negative bacteria in cystic fibrosis patients : the results of an Italian multicenter study. (1999) |
| Auteurs : | G. TACCETTI ; S. CAMPANA ; L. MARIANELLI ; Cystic Fibrosis Center. Meyer Hospital. University of Florence. ITA ; Italian Group for Cystic Fibrosis Microbiology. ITA |
| Type de document : | Article |
| Dans : | European journal of epidemiology (vol. 15, n° 1, 1999) |
| Pagination : | 85-88 |
| Langues: | Anglais |
| Mots-clés : | Mucoviscidose ; Bactériose ; Infection ; Médicament antibiotique ; Epidémiologie ; Thérapeutique médicamenteuse ; Thérapeutique ; Microbiologie ; Homme ; Italie ; Europe ; Appareil respiratoire [pathologie] ; Appareil digestif [pathologie] ; Pancréas [pathologie] ; Maladie héréditaire ; Métabolisme [pathologie] |
| Résumé : | [BDSP. Notice produite par INIST yDR0xdqA. Diffusion soumise à autorisation]. We carried out an epidemiological study on 2717 patients seen on a regular basis at Italian Cystic Fibrosis Centers with the aim of defining the prevalence of multiresistant Gram-negative strains in Italy. We found 272 multiresistant strains out of 1560 Gram-negative strains isolated in 1012 Italian cystic fibrosis patients. From our results in Italian cystic fibrosis patients we may conclude : (1) the beta-lactam antibiotics are moderately active ; ceftazidime is the most efficacious even if 59.9% of multiresistant strains are not sensitive to this drug ; (2) the aminoglycosides are poorly efficacious ; 93% of multiresistant strains are resistant in vitro to tobramycin ; and (3) the quinolones, notwithstanding their relatively recent introduction into clinical practice, have very poor activity against multiresistant strains, 89.7% of which are not sensitive. |
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