| Titre : | Smoking and the occurrence of Alzheimer's disease : Cross-sectional and longitudinal data in a population-based study. (1999) |
| Auteurs : | H.X. WANG ; L. FRATIGLIONI ; G.B. FRISONI ; M. VIITANEN ; B. Winblad ; Department of Clinical Neuroscience and Family Medicine. Division of Geriatric Medicine. Karolinska Institute. Stockholm. SWE ; Stockholm Gerontology Research Center. Stockholm. SWE |
| Type de document : | Article |
| Dans : | American journal of epidemiology (vol. 149, n° 7, 1999) |
| Pagination : | 640-644 |
| Langues: | Anglais |
| Mots-clés : | Démence Alzheimer ; Tabagisme ; Epidémiologie ; Incidence ; Prévalence ; Facteur risque ; Personne âgée ; Homme ; Suède ; Europe ; Système nerveux [pathologie] |
| Résumé : | [BDSP. Notice produite par INIST iL2uwR0x. Diffusion soumise à autorisation]. The authors tested the hypothesis that smoking exerts a protective effect on Alzheimer's disease or dementia in a population-based cohort of 668 people aged 75-101 years (Sweden). Smoking was negatively associated with prevalent Alzheimer's disease (adjusted odds ratio=0.6,95% confidence interval 0.4-1.1) and dementia (adjusted odds ratio=0.6,95% confidence interval 0.4-1.0). Over 3-year follow-up (1989-1992), the hazard ratios of incident Alzheimer's disease and dementia due to smoking were 1.1 (95% confidence interval 0.5-2.4) and 1.4 (95% confidence interval 0.8-2.7). Mortality over 5-year follow-up was greater among smokers in demented (hazard ratio=3.4) than nondemented (hazard ratio=0.8) subjects. Smoking does not seem protective against Alzheimer's disease or dementia, and the cross-sectional association might be due to differential mortality. |
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