| Titre : | Some life-style factors and the risk of invasive epithelial ovarian cancer in Swedish women. (2004) |
| Auteurs : | Tomas RIMAN ; Paul-W DICKMAN ; Cecilia-M MAGNUSSON ; Staffan NILSSON ; NORDLINDER (Hans) : SWE. Department of Pathology. Uppsala University. Uppsala. ; Ingemar-R PERSSON ; Center for Clinical Research. Dalarna. SWE ; Falu Hospital. Department of Obstetrics and Gynecology. Falun. SWE |
| Type de document : | Article |
| Dans : | European journal of epidemiology (vol. 19, n° 11, 2004) |
| Pagination : | 1011-1019 |
| Langues: | Anglais |
| Mots-clés : | Cancer ; Condition vie ; Facteur risque ; Suède ; Europe ; Femme ; Homme ; Epidémiologie |
| Résumé : | [BDSP. Notice produite par INIST-CNRS WR0xli53. Diffusion soumise à autorisation]. The objective of this nationwide case-control study was to examine body mass index (BMI), alcohol use, coffee consumption, cigarette smoking, and leisure-time physical activity in relation to epithelial ovarian cancer (EOC) risk. Subjects were 655 newly diagnosed EOC cases and 3899 population controls, all 50-74 years of age at recruitment between 1993 and 1995. Data were collected through mailed questionnaires. Odds ratios (ORs) and 95% confidence intervals (CIs) were estimated using unconditional logistic regression. Women with a BMI>=30 kg/m2 compared with those with a BMI<22 kg/m2 appeared to have an elevated EOC risk (OR=1.37,95% CI : 1.01-1.85), particularly of mucinous (OR=2.76,95% CI : 1.15-6.61) and clear-cell histologies (OR=2.68,95% CI : 0.96-7.48). The OR for EOC among coffee users reporting>=6 daily cups compared with non-users was 0.68 (95% CI : 0.42-1.10). Alcohol consumption was unrelated to EOC risk. Compared to non-smokers the ORs of EOC among current smokers were 0.70 (95% CI : 0.52-0.94) for those who smoked 1-10 cigarettes/day and 0.74 (95% CI : 0.53-1.02) for heavier smokers, while former smokers were at an unaltered risk (OR=0.83,95% CI : 0.66-1.04). Reduced EOC risks were observed among women in the highest compared with the lowest physical activity levels both at age 18-30 years (OR=0.67,95% CI : 0.52-0.87) and during the last years preceding study enrollment (OR=0.68,95% CI : 0.53-0.87). We conclude that women may avoid an excess risk of EOC through maintaining a normal BMI and reduce their risk by participation in leisure-time physical activity. The use of coffee, alcohol, or cigarette smoking does not appear to increase the risk of EOC. |
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