Titre : | Fetal HLA typing in bêta thalassaemia : implications for haemopoietic stem-cell transplantation. Commentary. (2003) |
Auteurs : | Maria-Grazia OROFINO ; Francesca ARGIOLU ; Manuela BADIALI ; Antonio CAO ; Paola COSSU ; J.D.A. DELHANTY ; Maria-Eliana LAI ; Rosalba PUDDU ; Maria-Cristina ROSATELLI ; Maria-Adele SANNA ; Maria-Teresa SCALAS ; Teresa TUVERI ; Universita degli Studi di Cagliari. Department of Biomedical Science and Biotechnology. Paediatric Clinic of the Bone Marrow Transplant Centre. Cagliari. ITA |
Type de document : | Article |
Dans : | Lancet (The) (vol. 362, n° 9377, 2003) |
Pagination : | 6-42 (3p.) |
Langues: | Anglais |
Mots-clés : | Examen complémentaire ; Foetus ; Thérapeutique ; Homme ; Hémopathie ; Hémoglobinopathie ; Maladie héréditaire |
Résumé : | [BDSP. Notice produite par INIST-CNRS bXR0xOKt. Diffusion soumise à autorisation]. Stem-cell transplantation can cure bêta thalassaemla. We aimed to assess whether fetal HLA typing done early In the pregnancy of couples who were at risk of bêta thalassaemia could provide an alternative to pregnancy termination if the prospect of a bone-marrow transplantation from a family member was available. In our clinic in Sardinia, we did fetal HLA typing for 49 couples at risk of having a baby with bêta thalassaemla. Two affected children were born and successfully received a transplantation from a family donor. Five non-affected fetuses were HLA compatible with an affected sibling and their cord blood was harvested for a future transplantation. |