Titre : | Decline in the AIDS and death rates in the EuroSIDa study : an observational study. (2003) |
Auteurs : | A. MOCROFT ; A. D'ARMINIO MONFORTE ; M. DIETRICH ; C. KATLAMA ; O. KIRK ; B. KNYSZ ; B. LEDERGERBER ; J.D. LUNDGREN ; A.N. PHILLIPS ; P. REISS ; EuroSida study group. EUR ; Hyidovre Hospital. Hvidovre. DNK ; Royal Free Centre for Hiv Medicine and Department of Primary Care and Population Sciences. Royal Free and University College Medical School. London. GBR |
Type de document : | Article |
Dans : | Lancet (The) (vol. 362, n° 9377, 2003) |
Pagination : | 22-29 |
Langues: | Anglais |
Mots-clés : | Sida ; Virose ; Infection ; Thérapeutique ; Thérapeutique médicamenteuse ; Chimiothérapie ; Etude comparée ; Médicament antiviral ; Epidémiologie ; Incidence ; Homme ; Europe ; Argentine ; Amérique ; Israël ; Asie ; Immunopathologie ; Amérique du Sud |
Résumé : | [BDSP. Notice produite par INIST-CNRS JHS3cR0x. Diffusion soumise à autorisation]. Background : Since the introduction of highly active antiretroviral therapy (HAART), little is known about whether changes in HIV-1 mortality and morbidity rates have been sustained. We aimed to assess possible changes in these rates across Europe. Methods : We analysed data for 9803 patients in 70 European HIV centres including ones in Israel and Argentina. Incidence rates of AIDS or death were calculated for overall and most recent CD4 count in 6-monthly periods and in three treatment eras (pre-HAART, 1994-1995 ; early-HAART, 1996-1997 ; and late-HAART, 1998-2002). Findings : The incidence of AIDS or death fell after September, 1998, by 8% per 6-month period (rate ratio 0.92,95% Cl 0.88-0.95, p |