| Titre : | Results of repeat sigmoidoscopy 3 years after a negative examination. (2003) |
| Auteurs : | Robert-E SCHOEN ; Robert-S BRESALIER ; Timothy CHURCH ; John-K GOHAGAN ; Paul-F PINSKY ; Philip PROROK ; Joel-L WEISSFELD ; Departments of Medicine and Epidemiology and the University of Pittsburgh Cancer Institute. University of Pittsburgh. Pittsburgh. PA. USA ; Division of Cancer Prevention. National Cancer Institute. Bethesda. MD. USA |
| Type de document : | Article |
| Dans : | JAMA - Journal of the american medical association (vol. 290, n° 1, 2003) |
| Pagination : | 41-48 |
| Langues: | Anglais |
| Mots-clés : | Evolution ; Dépistage ; Cancer ; Rectum ; Homme ; Appareil digestif [pathologie] ; Intestin [pathologie] ; Tumeur bénigne ; Endoscopie ; Côlon |
| Résumé : | [BDSP. Notice produite par INIST-CNRS S81UHR0x. Diffusion soumise à autorisation]. Context : The necessary frequency of endoscopic colorectal cancer screening after a negative examination is uncertain. Objective : To examine the yield of adenomas and cancer in the distal colon found by repeat flexible sigmoidoscopy (FSG) 3 years after a negative examination. Design, Setting, and Participants Participants were drawn from the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial (PLCO), a randomized, controlled community-based study of cancer screening. The mean (SD) age was 65.7 (4.0) years at study entry (1993-1995) and 61.6% were men. Individuals underwent screening FSG at baseline and at 3 years as part of the protocol and were referred to their personal physicians for further evaluation of screen-detected abnormalities. Results from subsequent diagnostic evaluations were tracked in a standardized fashion. Of 11583 eligible for repeat screening FSG 3 years after an initial negative examination, 9317 (80.4%) returned. Main Outcome Measures Polyp or mass detection in distal colon at year 3 repeat FSG ; incidence of adenoma or cancer in distal colon at year 3 examination ; determination of reason for detection (increased depth of insertion or improved preparation at the year 3 examination or detection in a previously examined area). Results A total of 1292 returning participants (13.9%) had a polyp or mass detected by FSG 3 years after the initial examination. In the distal colon, 3.1% (292/9317) were found to have an adenoma or cancer. The incidence of advanced adenoma (n=72) or cancer (n=6) in the distal colon was 78 (0.8%) of 9317. Of individuals with advanced distal adenomas detected at the year 3 examination, 80.6% (58/72) had lesions found in a portion of the colon that had been adequately examined at the initial sigmoidoscopy. Conclusions : Repeat FSG 3 years after a negative examination will detect advanced adenomas and distal colon cancer. Although the overall percentage with detected abnormalities is modest, these data raise concern about the impact of a prolonged screening interval after a negative examination. |
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