| Titre : | Cortisol, estrogens and risk of ischaemic heart disease, cancer and all-cause mortality in postmenopausal women : a prospective cohort study. (2010) |
| Auteurs : | Naja HULVEJ ROD ; Finn DIDERICHSEN ; Ase-Marie Hansen ; JENSEN (Gorm-B) : DNK. The Copenhagen City Heart Study. Epidemiological Research Unit. Bispebjerg University Hospital. Copenhagen. ; KRISTENSEN (Tage-S) : DNK. Task-Consult. Copenhagen. ; PRESCOTT (Eva) : DNK. Department of Cardiology. Bispebjerg University Hospital. Copenhagen. |
| Type de document : | Article |
| Dans : | International journal of epidemiology (vol. 39, n° 2, 2010) |
| Pagination : | 530-538 |
| Langues: | Anglais |
| Mots-clés : | Facteur risque ; Risque ; Cardiopathie coronaire ; Facteur ; Mortalité ; Epidémiologie ; Cancer ; Femme ; Etude prospective ; Pathologie ; Médicament antiinflammatoire ; Psychologie ; Stress ; Homme ; Corticostéroïde |
| Résumé : | [BDSP. Notice produite par INIST-CNRS jR0x87CJ. Diffusion soumise à autorisation]. Background Chronic stress may affect morbidity and mortality through neuroendocrine changes, and the ratio of cortisol to sex steroid hormones has been suggested as a biomarker of stress. We aim to address a relation between the ratio of cortisol to estrogens (C/E) and risk of ischaemic heart disease (IHD), hormone-dependent cancers and all-cause mortality among postmenopausal women. Methods Estradiol and cortisol were measured in a subset of 838 women randomly drawn from the second wave of the Copenhagen City Heart Study (n=5297 examined in 1981-83) as well as among all women who developed hormone-dependent cancers after baseline. The participants were followed in nationwide registers until 2007, with<0.1% loss to follow-up. Results The C/E ratio was not associated with self-reported stress, and there were no clear associations with IHD (highest vs lowest quartile : HR=1.23 ; 95% confidence interval 0.83-1.81), hormone-dependent cancers (0.69 ; 0.45-1.08) or all-cause mortality (1.10 ; 0.86-1.41). Conclusions The C/E ratio was not associated with morbidity and mortality in women, and we cannot replicate the robust findings of a relation between the cortisol to testosterone ratio and IHD previously reported in men. Whether the C/E ratio is a reasonable biomarker of stress is debatable. |
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