| Titre : | Serum dioxin concentrations and risk of uterine leiomyoma in the seveso women's health study. (2007) |
| Auteurs : | Brenda ESKENAZI ; Nicoletta GAVONI ; Pier-Mario GERTHOUX ; Paolo MOCARELLI ; Larry NEEDHAM ; OLIVE (David) : USA. Department of Obstetrics and Gynecology. University of Wisconsin Medical School. Madison. WI. ; Donald PATTERSON ; SAMUELS (Steven) : USA. Department of Epidemiology. School of Public Health. State University of New York at Albany. Albany. NY. ; Paolo VERCELLINI ; Marcella WARNER ; Jessica YOUNG ; Centers for Disease Control and Prevention. National Center for Environmental Health. Division of Laboratory Science. Atlanta. GA. USA ; University of California. School of Public Health. Department of Epidemiology. Berkeley. CA. USA ; University of Milan. Mangiagalli Hospital. Department of Obstetrics and Gynecology. Milan. ITA ; University of Milano-Bicocca. Hospital of Desio. School of Medicine. Department of Laboratory Medicine. Desio Milano. ITA |
| Type de document : | Article |
| Dans : | American journal of epidemiology (vol. 166, n° 1, 2007) |
| Pagination : | 79-87 |
| Langues: | Anglais |
| Mots-clés : | Sérum ; Concentration ; Facteur risque ; Risque ; Femme ; Homme ; Epidémiologie ; Dioxine ; Utérus [pathologie] ; Tumeur bénigne |
| Résumé : | [BDSP. Notice produite par INIST-CNRS RAR0xm38. Diffusion soumise à autorisation]. Uterine leiomyomata (fibroids), benign neoplasms of the smooth muscle, are a major cause of hysterectomy. Exposure to hormonally active chemicals may play an etiologic role. The authors investigated the risk of uterine leiomyoma associated with exposure to 2,3,7,8, - tetrachlorodibenzo-p-dioxin (TCDD) for women who resided near Seveso, Italy, in 1976 at the time of a chemical explosion. Twenty years later, women enrolled in the Seveso Women's Health Study were asked about history of fibroids, medical records were obtained, and vaginal ultrasonography was performed for a subset. Serum collected soon after the explosion was analyzed for TCDD. A likelihood-based method that combines both historical and current status (ultrasound) data was adapted to estimate the hazard ratio. Of 956 eligible women, 251 (26.3%) had fibroids. Compared with that for women with TCDD levels of<20 parts per trillion, the age-adjusted hazard ratios were 0.58 (95% confidence interval : 0.41,0.81) for women with levels of 20.1-75.0 parts per trillion and 0.62 (95% confidence interval : 0.44,0.89) for women with levels of>75.0 parts per trillion. This finding suggests that TCDD may have antiestrogenic effects in the uterine myometrium, in contrast to apparently estrogenic effects previously found in the breast of Seveso Women's Health Study women. |
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