| Titre : | Serum concentrations of organochlorine compounds and K-ras mutations in exocrine pancreatic cancer. (1999) |
| Auteurs : | M. PORTA ; M. ANDREU ; A. CARRATO ; J.M. COROMINAS ; J.O. GRIMALT ; L. GUARNER ; M. JARIOD ; N. MALATS ; F.X. REAL ; J. RIFA ; A. SALAS ; M. SANTIAGO-SILVA ; Department of Environmental Chemistry. Institute of Chemical and Environmental Research Csic Barcelona. ESP ; Institut Municipal d'Investigaclo Mèdica. Universitat Aut noma de Barcelona and Universitat Pompeu Fabra. Barcelona. ESP ; Pankras Ii Study Group. ESP |
| Type de document : | Article |
| Dans : | Lancet (The) (vol. 354, n° 9196, 1999) |
| Pagination : | 2125-2129 |
| Langues: | Anglais |
| Mots-clés : | Cancer ; Concentration ; Plasma sanguin ; Exposition ; Exposition professionnelle ; Condition vie ; Epidémiologie ; Homme ; Appareil digestif [pathologie] ; Pancréas [pathologie] |
| Résumé : | [BDSP. Notice produite par INIST R0x82mQ2. Diffusion soumise à autorisation]. Background Organochlorine compounds such as 1,1,1-trichloro-2,2-bis (p-chlorophenyl) - ethane (p, p'-DDT), 1,1-dichloro-2,2-bis (p-chlorophenyl) ethylene (p, p'-DDE), and some polychlorinated biphenyls (PCBs) are carcinogenic to animals and possibly also to human beings. Occupational exposure to DDT may increase the risk of pancreas cancer. The high frequency of K-ras mutations in pancreatic cancer remains unexplained. We analysed the relation between serum concentrations of selected organochlorine compounds and mutations in codon 12 of the K-ras gene in patients with exocrine pancreatic cancer. Methods Cases were prospectively identified in five hospitals. Mutations in K-ras were analysed by PCR and artificial restriction fragment length polymorphism. Cases of pancreatic cancer with wild-type K-ras (n=17) were frequency matched for age and sex to cases of pancreatic cancer with a K-ras mutation (n=34, case-case study). These 51 cases were further compared with 26 hospital controls (case-control comparison). Serum organochlorine concentrations were measured by high-resolution gas chromatography with electron capture detection and negative ion chemical ionisation mass spectrometry. Findings Serum concentrations of p, p'-DDT were significantly higher in pancreatic cancer cases with a K-ras mutation than in cases without a mutation (odds ratio for upper tertile 8.7 [95% Cl 1.6-48.5], p for trend=0.005). For p, p'-DDE the corresponding figures were 5.3 (1.1-25. (...) |
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