Titre :
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Influence of MHC class II genotype on outcome of infection with hepatitis C virus. (1999)
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Auteurs :
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M. THURSZ ;
R. GOLDIN ;
H.C. Thomas ;
C. TREPO ;
R. YALLOP ;
Hepatology Section. Division of Medicine A. Imperial College School of Medicine at St Mary's Hospital. London. GBR
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Type de document :
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Article
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Dans :
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Lancet (The) (vol. 354, n° 9196, 1999)
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Pagination :
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2119-2124
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Langues:
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Anglais
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Mots-clés :
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Hépatite virale C
;
Virose
;
Infection
;
Etude comparée
;
Pronostic
;
Homme
;
Europe
;
Epidémiologie
;
Appareil digestif [pathologie]
;
Foie [pathologie]
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Résumé :
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[BDSP. Notice produite par INIST 2BR0xZ5C. Diffusion soumise à autorisation]. Background The outcome of infection with hepatitis C virus (HCV) varies substantially among individuals. Host genetic factors are likely to give rise to some of this variability. Polymorphisms in the MHC class II loci may influence the outcome of HCV infection ; however, reports of MHC class II allele associations have been inconsistent. We aimed to confirm these associations in a cohort of European patients with different clinical outcomes. Methods The distribution of MHC class II alleles was compared between patients with self-limiting infection (n=85) and matched patients with persistent infection (n=170) ; between patients with mild (n=321) and severe (n=321) histological injury ; and between patients who responded to interferon (n=96) and those who did not (n=192). The results of these comparisons were confirmed with a second-stage study of self-limiting infection (n=52) versus persistent infection (n=152). Findings Self-limiting HCV infection was associated with HLA-DRB1*1101 (odds ratio 2.14 [95% Cl 1.11-4.12] ; p=0.013) and HLA-DQB1*0301 (2.22 [1.24-3.96], p=0.004). Persistent HCV infection was associated with HLA-DRB1*0701 (2.04 [1.03-4.17], p=0.027), and HLA-DRB4*0101 (2.38 [1.29-4.35], p=0.002). These results were confirmed in the second-stage study. No significant associations (p
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