| Titre : | Gender-dependent differences in outcome after the treatment of infection in hospitalized patients. (1999) |
| Auteurs : | T.D. CRABTREE ; T.G. GLEASON ; S.J. Pelletier ; T.L. PRUETT ; L. PRUETT ; R.G. SAWYER ; Department of Surgery. University of Virginia Health Sciences Center. Charlottesville. USA |
| Type de document : | Article |
| Dans : | JAMA - Journal of the american medical association (vol. 282, n° 22, 1999) |
| Pagination : | 2143-2148 |
| Langues: | Anglais |
| Mots-clés : | Infection ; Hospitalisation ; Mortalité ; Facteur risque ; Sexe ; Homme ; Résultat |
| Résumé : | [BDSP. Notice produite par INIST n9561R0x. Diffusion soumise à autorisation]. Context While it is established that management strategies and outcomes differ by gender for many diseases, its effect on infection has not been adequately studied. Objective To investigate the role of gender among hospitalized patients treated for infection. Design Observational cohort study conducted during a 26-month period from December 1996 through January 1999. Setting University-affiliated hospital. Participants A total of 892 patients in the surgical units of the hospital with 1470 consecutive infectious episodes (782 in men and 688 in women). Main Outcome Measures Mortality during hospitalization by gender for infection episodes overall and for specific infectious sites, including lung, peritoneum, bloodstream, catheter, urine, surgical site, and skin/soft tissue. Results Among all infections, there was no significant difference in mortality based on gender (men, 11.1% vs women, 14.2% ; P=07). After logistic regression analysis, factors independently associated with mortality included higher APACHE (Acute Physiology and Chronic Health Evaluation) II score, older age, malignancy, blood transfusion, and diagnosis of infection more than 7 days after admission, but not gender (female odds ratio [OR] for death, 1.32 ; 95% confidence interval [CI], 0.90-1.94 ; P=16). Mortality was higher in women for lung (men, 18% vs women, 34% ; P=002) and soft tissue (men, 2% vs women, 10% ; P<=. 05) infection ; for other infectious sites, mortality did not differ by gender. (...) |
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