| Titre : | Risk factors for popliteal and carotid wall thicknesses in the Atherosclerosis Risk in Communities (ARIC) Study. (1999) |
| Auteurs : | A.S. DOBS ; R. BARNES ; W.J. KO ; F.J. NIETO ; A.R. SHARRETT ; M. SZKLO ; Aric Study Group. USA ; Department of Epidemiology. The Johns Hopkins University School of Hygiene and Public Health. Baltimore. MD. USA |
| Type de document : | Article |
| Dans : | American journal of epidemiology (vol. 150, n° 10, 1999) |
| Pagination : | 1055-1067 |
| Langues: | Anglais |
| Mots-clés : | Artériosclérose ; Epidémiologie ; Facteur risque ; Homme ; Etats Unis ; Amérique ; Appareil circulatoire [pathologie] ; Vaisseau sanguin [pathologie] ; Amérique du Nord |
| Résumé : | [BDSP. Notice produite par INIST zsPR0xs5. Diffusion soumise à autorisation]. The authors evaluated risk factors potentially associated with the development of popliteal artery atherosclerosis in a population-based study and compared them with factors linked to carotid wall intimal-medial thickness. The Atherosclerosis Risk in Communities (ARIC) Study is a longitudinal investigation of cardiovascular disease in 15,800 individuals. The present analyses are based on the baseline popliteal and carotid ultrasonography examination in 10,002 subjects conducted in 1987-1989. After adjustment for covariates, both carotid and popliteal intimal-medial thicknesses were strongly associated with male sex and age (p<0.01), having a graded relation with increasing quartiles of plasma total cholesterol and low density lipoprotein cholesterol and with plasma triglycerides (women only for popliteal) (p<0.01). An inverse correlation was noted between plasma high density lipoprotein cholesterol and carotid (p<0.01) and popliteal (women only) (p<0.05) intimal-medial thicknesses. Cigarette use (p<0.01), a history of diabetes mellitus (p<0.01), alcohol use, elevated systolic pressures (p<0.01), and fibrinogen levels (p<0.01) were directly associated with both popliteal and carotid intimal-medial thicknesses. Although menopause was associated with thickened carotid (p<0.01) and popliteal (p<0.05) intimal-medial thicknesses, hormone replacement therapy was associated with thinner carotid walls only (p<0.05). (...) |
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