| Titre : | Similarities in the epidemiology of neural tube defects and coronary heart disease : is homocysteine the missing link ? (1999) |
| Auteurs : | D.H. STONE ; P. MCCARRON ; G.D. Smith ; Department of Social Medicine. University of Bristol. GBR |
| Type de document : | Article |
| Dans : | Journal of epidemiology and community health (vol. 53, n° 12, 1999) |
| Pagination : | 789-793 |
| Langues: | Anglais |
| Mots-clés : | Malformation tube neural ; Malformation ; Maladie congénitale ; Cardiopathie coronaire ; Prévalence ; Evolution ; Etiologie ; Nouveau né ; Homme ; Epidémiologie ; Royaume Uni ; Europe ; Appareil circulatoire [pathologie] |
| Résumé : | [BDSP. Notice produite par INIST R0xaw5fQ. Diffusion soumise à autorisation]. It is hypothesised that a single aetiological pathway could explain both the strong ecological association between the birth prevalence of neural tube defects (NTD) and coronary heart disease (CHD) mortality and the potential efficacy of dietary measures, especially increased folic acid intake, in their prevention. The epidemiological similarities between NTD and CHD are strong and consistent suggesting that the relation is real rather than artefactual. It is suggested that this epidemiological association reflects a shared aetiology arising from the role of disturbed homocysteine metabolism in the pathogenesis of both conditions. Current public health measures designed to increase the intake of periconceptional folic acid in women, reinforced by a broadening of this policy to target both sexes throughout life, will (if successful) result in a reduction in both the birth prevalence of NTD and the incidence of CHD, although not necessarily contemporaneously. If disordered homocysteine metabolism is the cause of both NTD and CHD, this has implications for future research and preventive strategies for these serious and often lethal diseases. |
Service Documentation EHESP
Me connecter
PORTAIL DOCUMENTAIRE
École des hautes études en santé publique
Catalogue
Multi-bases
Accueil
Sélection de la langue
Adresse
Service Documentation EHESPBibliothèque Rennes Avenue du Professeur Léon Bernard – CS 74312 – 35043 Rennes Cedex Bibliothèque MSSH Paris 20 avenue George Sand - 93210 La Plaine Saint-Denis
France
Bibliothèque Rennes : 02 99 02 29 50 Bibliothèque MSSH Paris : 02 99 02 24 50
contact