| Titre : | Risk of cancer after use of fertility drugs with in-vitro fertilisation. (1999) |
| Auteurs : | A. VENN ; F. BRUINSMA ; G. GILES ; D. HEALY ; L. WATSON ; Centre for the Study of Mothers'and Children's Health. La Trobe University. Carlton Victoria. AUS |
| Type de document : | Article |
| Dans : | Lancet (The) (vol. 354, n° 9190, 1999) |
| Pagination : | 1586-1590 |
| Langues: | Anglais |
| Mots-clés : | Insémination artificielle ; Association ; Facteur risque ; Résultat ; Femme ; Australie ; Océanie ; Homme ; Grossesse ; Cancer ; Statistique |
| Résumé : | [BDSP. Notice produite par INIST SW4ER0xU. Diffusion soumise à autorisation]. Background We investigated the incidence of invasive cancer of the breast, ovary, and uterus in a cohort of patients who had undergone in-vitro-fertilisation (IVF) treatment and examined whether cause of infertility or exposure to fertility drugs to induce superovulation was associated with an increased cancer risk. Method Ten Australian IVF clinics provided data for women who had been referred for IVF before Jan 1,1994. The frequencies of invasive breast, ovarian, and uterine cancer were assessed by record linkage to population-based cancer registries and the national death index. The observed number of cancers was compared with the expected number calculated by application of age-standardised general-population cancer rates to the cohort. Standardised incidence ratios (SIRs) were derived from the ratio of observed to expected cases. Findings The cohort consisted of 29 700 women : 20 656 were exposed to fertility drugs and 9044 were not. 143 breast cancers, 13 ovarian cancers, and 12 cancers of the uterus occurred among these women. For breast and ovarian cancer the incidence was no greater than expected (SIR 0.91 [95% Cl 0.74-1.13] for breast cancer and 0-88 [0.42-1.84] for ovarian cancer in the exposed group and 0.95 [0.73-1.23] for breast cancer and 1.16 [0.52-2.59] for ovarian cancer in the unexposed group). The incidence of uterine cancer was no higher than expected in the exposed group (1.09 [0.45-2.61]) but was significantly higher in the unexposed group (2. (...) |
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