| Titre : | Associations between stomach cancer incidence and drinking water contamination with atrazine and nitrate in Ontario (Canada) agroecosystems, 1987-1991. (1999) |
| Auteurs : | J.A. VAN LEEUWEN ; T. ABERNATHY ; M. SHOUKRI ; B. SMIT ; D. Waltner-Toews ; Department of Population Medicine. University of Guelph. Guelph. ON. CAN |
| Type de document : | Article |
| Dans : | International journal of epidemiology (vol. 28, n° 5, 1999) |
| Pagination : | 836-840 |
| Langues: | Anglais |
| Mots-clés : | Cancer ; Estomac ; Eau [boisson] ; Pollution eau ; Nitrate ; Agriculture ; Produit chimique ; Epidémiologie ; Facteur risque ; Homme ; Canada ; Amérique ; Appareil digestif [pathologie] ; Estomac [pathologie] ; Amérique du Nord |
| Résumé : | [BDSP. Notice produite par INIST 1R0x0UCW. Diffusion soumise à autorisation]. Background Nitrate and atrazine are two chemicals that are heavily used in certain sectors of agriculture. They are suspected to be associated with the development of certain types of tumours. Methods Existing data were obtained on the incidence of specific types of cancers, contamination of drinking water with atrazine and nitrate, and related agricultural practices for the 40 ecodistricts in the province of Ontario. The data were merged into a georelational database for geographical and statistical analyses. Weighted (by population size) least squares regression analyses were conducted while controlling for confounding socioeconomic and lifestyle factors. Maximum likelihood spatial error models were estimated when least square regression error terms were found to be spatially autocorrelated using the Moran's I statistic. Results Atrazine contamination levels (range 50-649 ng/l, maximum acceptable concentration [MAC]=60 000 ng/l) were positively associated (P<0.05) with stomach cancer incidence and negatively associated with colon cancer incidence. Nitrate levels, (range 0-91 mg/l, MAC=10 mg/l) were negatively associated with stomach cancer incidence. (...) |
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