| Titre : | GSTM1, smoking and lung cancer : a case-control study. (1999) |
| Auteurs : | I. STUCKER ; P. BEAUNE ; Jean Bignon ; S. CENEE ; I. DE WAZIERS ; A. DEPIERRE ; D. HEMON ; B. MILLERON ; Inserm U75. Hôpital Necker. Paris. FRA ; Unité de Recherches Epidémiologiques et Statistiques sur l'Environnement et la Santé Epidemiologic and Statistical Research on Environment and Health Inserm U 170. Villejuif. FRA |
| Type de document : | Article |
| Dans : | International journal of epidemiology (vol. 28, n° 5, 1999) |
| Pagination : | 829-835 |
| Langues: | Anglais |
| Mots-clés : | Cancer ; Poumon ; Tabagisme ; Génétique ; Epidémiologie ; Facteur risque ; Homme ; France ; Europe ; Appareil respiratoire [pathologie] |
| Résumé : | [BDSP. Notice produite par INIST yR0xrXBM. Diffusion soumise à autorisation]. Background We conducted a case-control study to examine the risk of lung cancer in relation to GSTMI polymorphism and cigarette smoking (primarily of black tobacco) in a French population. Methods The 611 subjects were 301 incident lung cancer cases and 310 hospital controls. We were able to constitute a DNA bank for 547 subjects (89.5%) and gather detailed information on smoking history for all of them. Results presented here concern 247 cases and 254 controls. Results Taking non-or light smokers as the reference category, we estimated odds ratios (OR) of 4.2 (95% CI : 2.6-6.7) and 5.2 (95% CI : 3.3-8.3) for the medium and heavy smokers respectively. On the other hand we estimated that the crude OR associating GSTMI with lung cancer was 1.3 (95% CI : 0.9-1.8). Furthermore our data do not depart significantly from a multiplicative model of the combined effects of smoking and GSTM1 deficiency. Conclusions We conclude that smoking and the GSTM1 gene are each a risk factor for lung cancer, and that their combined effect does not differ significantly from that of a multiplicative model. |
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