| Titre : | Failure of secondary infection with American genotype dengue 2 to cause dengue haemorrhagic fever. (1999) |
| Auteurs : | D.M. WATTS ; C. CALAMPA ; S.B. HALSTEAD ; C.G. HAYES ; K.R. PORTER ; P. PUTVATANA ; B. VASQUEZ ; Centro Medico Naval. Peruvian Navy. Bellavista Callao. PER |
| Type de document : | Article |
| Dans : | Lancet (The) (vol. 354, n° 9188, 1999) |
| Pagination : | 1431-1434 |
| Langues: | Anglais |
| Mots-clés : | Dengue ; Virose ; Infection ; Virus ; Examen sérologique ; Surveillance épidémiologique ; Epidémiologie ; Etiologie ; Homme ; Pérou ; Amérique ; Amérique du Sud |
| Résumé : | [BDSP. Notice produite par INIST HbR0xLW9. Diffusion soumise à autorisation]. Background Population-based epidemiological studies have shown that infection with dengue type 2 (DEN-2) virus in individuals previously infected with a different serotype of the virus is a major risk factor for dengue haemorrhagic fever and dengue shock syndrome. However, the western hemisphere was spared epidemics of these two syndromes, until the introduction of a southeast Asian DEN-2 genotype. Possibly American DEN-2 genotype strains lacked properties necessary to cause severe disease. We report on a major epidemic of DEN-2 in Peru in 1995, about 5 years after an epidemic of DEN-1 in the same population. Methods In lquitos, a city of 344 686 inhabitants in Peru, cases of dengue fever were studied prospectively from 1990. Acute phase of illness serum samples from patients were tested for virus in C6/36 cells, and virus isolates were identified by immunofluorescence. Isolates of dengue 2 virus obtained from patients during an outbreak of mild febrile illness in 1995 were sequenced to determine the genotype. Serological analysis of paired samples from the patients was done with an IgM capture ELISA and an indirect IgG ELISA. In addition, serum samples collected annually between 1993 and 1996 from a large cohort of students were tested for dengue lgG antibody by an ELISA. Serum samples from a random sample of 129 students from this cohort were tested for dengue neutralising antibodies to quantify the serotype specific infection rates. (...) |
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