| Titre : | Association between coffee drinking and K-ras mutations in exocrine pancreatic cancer. (1999) |
| Auteurs : | M. PORTA ; M. ANDREU ; A. CARRATO ; J.M. COROMINAS ; L. GUARNER ; N. MALATS ; F.X. REAL ; J. RIFA ; A. SALAS ; Institut Municipal d'Investigacio Mèdica. Barcelona. ESP ; Pankras Ii Study Group. ESP |
| Type de document : | Article |
| Dans : | Journal of epidemiology and community health (vol. 53, n° 11, 1999) |
| Pagination : | 702-709 |
| Langues: | Anglais |
| Mots-clés : | Café ; Consommation ; Cancer ; Génétique ; Epidémiologie ; Facteur risque ; Homme ; Espagne ; Europe ; Alimentation ; Appareil digestif [pathologie] ; Pancréas [pathologie] |
| Résumé : | [BDSP. Notice produite par INIST G7HcIR0x. Diffusion soumise à autorisation]. Study objective-To analyse the relation between coffee consumption and mutations in the K-ras gene in exocrine pancreatic cancer. Design-Case-case study. Consumption of coffee among cases with the activating mutation in the K-ras gene was compared with that of cases without the mutation. Setting and patients-All cases of pancreatic cancer newly diagnosed at five hospitals in Spain during three years were included in the PANKRAS II Study (n=185, of whom 121 whose tissue was available for molecular analysis are the object of the present report). Over 88% were personally interviewed in hospital. DNA was amplified from paraffin wax embedded tissues, and mutations in codon 12 of K-ras were detected by the artificial RFLP technique. Main results-Mutations were found in tumours from 94 of 121 patients (77.7%). Mutations were more common among regular coffee drinkers than among non-regular coffee drinkers (82.0% v 55.6%, p=0.018, n=107). The odds ratio adjusted by age, sex, smoking and alcohol drinking was 5.41 (95% CI 1.64,17.78). The weekly intake of coffee was significantly higher among patients with a mutated tumour (mean of 14.5 cups/week v 8.8 among patients with a wild type tumour, p<0.05). With respect to non-regular coffee drinkers, the odds ratio of a mutated tumour adjusted by age, sex, smoking and alcohol drinking was 3.26 for drinkers of 2-7 cups/week, 5.77 for drinkers of 8-14 cups/week and 9.99 for drinkers of >=15 cups/week (p<0.01, test for trend). (...) |
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