| Titre : | Influenza vaccines : Antibody responses to split virus and MF59-adjuvanted subunit virus in an adult population. (1999) |
| Auteurs : | T. MENEGON ; V. BALDO ; C. BONELLO ; D.D. COSTA ; A. DI TOMMASO ; R. TRIVELLO ; Institute of Hygiene. University of Padua. Padua. IND ; Public Health Department. Dolo Local Health District. Venice. ITA |
| Type de document : | Article |
| Dans : | European journal of epidemiology (vol. 15, n° 6, 1999) |
| Pagination : | 573-576 |
| Langues: | Anglais |
| Mots-clés : | Vaccination ; Grippe ; Virose ; Infection ; Anticorps ; Examen sérologique ; Plasma sanguin ; Epidémiologie ; Evaluation ; Efficacité ; Adulte ; Homme ; Italie ; Europe |
| Résumé : | [BDSP. Notice produite par INIST jvR0x1BQ. Diffusion soumise à autorisation]. The humoral immune response generated by two commercial influenza vaccines was evaluated in a randomised, double-blind trial performed in the Public Department of Dolo Health District (Northeast Italy) during the winter season 1997-1998. Ninety-eight subjects were immunised with a split virus vaccine and ninety-six with a MF59-adjuvanted subunit virus vaccine (SU/MF59). The pre-and postvaccination (~30 days) antibody titres were determined by hemagglutination inhibition test (HI). After immunisation protective titre rates (>=1 : 40) were near 100% against virus A strain and 82.5% against B strain. Both vaccines caused significant rises in geometric mean antibody titres (GMTs) ; however, people who received SU/MF59 vaccine were found to develop a greater immune response compared to the group immunised with SVV. According to logistic regression analysis the unprotective prevaccination immune status and the use of SU/MF59 were identified as independent factors significantly increasing the response to immunisation. |
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