| Titre : | Plasma fatty acid composition and 6-year incidence of hypertension in middle-aged adults : The Atherosclerosis Risk in Communities (ARIC) Study. (1999) |
| Auteurs : | Z.J. ZHENG ; D.K. ARNETT ; J.H. ECKFELDT ; A.R. FOLSOM ; JING MA . (.) ; P.G. MCGOVERN ; Aric Study Group. INC ; Division of Epidemiology. School of Public Health. University of Minnesota. Minneapolis. MN. USA |
| Type de document : | Article |
| Dans : | American journal of epidemiology (vol. 150, n° 5, 1999) |
| Pagination : | 492-500 |
| Langues: | Anglais |
| Mots-clés : | Hypertension artérielle ; Plasma sanguin ; Ratio ; Epidémiologie ; Facteur risque ; Incidence ; Adulte ; Homme ; Etats Unis ; Amérique ; Appareil circulatoire [pathologie] ; Acide gras ; Amérique du Nord |
| Résumé : | [BDSP. Notice produite par INIST TR0x61pB. Diffusion soumise à autorisation]. The association of baseline fatty acid composition in plasma cholesterol esters with 6-year incidence of hypertension was examined in middle-aged Minneapolis participants of the Atherosclerosis Risk in Communities (ARIC) Study (1987-1995). Compared with those who were never hypertensive (n=1,975), incident hypertensives (n=413) had statistically significantly higher baseline levels of palmitic (16 : 0) and palmitoleic (16 : 1n7) acids but lower levels of linoleic (18 : 2n6) acid and the polyunsaturated/saturated fatty acids ratio (P/S ratio). Among polyunsaturated fatty acids, levels of dihomo-gamma-linolenic (20 : 3n6) and arachidonic (20 : 4n6) acids were statistically significantly higher in incident hypertensives, compared with normotensives. After adjustment for age, sex, body mass index, waist/hip ratio, smoking status, ethanol intake, education level, physical activity, and baseline systolic blood pressure in separate models, the odds ratio estimates of incident hypertension for an interquartile increment of a fatty acid in cholesterol esters were 1.26 (95% confidence interval (Cl) : 1.05,1.51) for 16 : 0,1.11 (95% Cl : 0.96,1.28) for 16 : 1n7,1.01 (95% Cl : 0.85,1.21) for 20 : 3n6,1.14 (95% Cl : 1.03,1.27) for 20 : 5n3,0.81 (95% CI : 0.68,0.96) for 18 : 2n6, and 0.83 (95% Cl : 0.70,0.99) for the P/S ratio. (...) |
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