| Titre : | Eosinophilia and positive skin tests predict cardiovascular mortality in a general population sample followed for 30 years. (1999) |
| Auteurs : | J.J. HOSPERS ; D.S. POSTMA ; B. RIJCKEN ; J.P. SCHOUTEN ; S.T. Weiss ; Dept of Epidemiology and Statistics. University of Groningen. Groningen. NLD |
| Type de document : | Article |
| Dans : | American journal of epidemiology (vol. 150, n° 5, 1999) |
| Pagination : | 482-491 |
| Langues: | Anglais |
| Mots-clés : | Appareil circulatoire [pathologie] ; Mortalité ; Allergène ; Sang ; Asthme ; Allergie ; Epidémiologie ; Facteur risque ; Homme ; Europe ; Appareil respiratoire [pathologie] ; Bronchopneumopathie obstructive ; Immunopathologie ; Pays Bas |
| Résumé : | [BDSP. Notice produite par INIST 2pdvRR0x. Diffusion soumise à autorisation]. The authors investigated whether two objective allergy markers, peripheral blood eosinophilia and skin tests for common aeroallergens, were associated with cardiovascular death. Of 5,382 subjects in the Vlagtwedde-Vlaardingen Study (the Netherlands) with data on allergy markers in 1965-1972,507 subjects died from cardiovascular disease during 30 years of follow-up. Subjects with eosinophilia had an increased risk of cardiovascular death (relative risk (RR)=1.7 ; 95% confidence interval (Cl) : 1.4,2.2), including ischemic heart disease death (RR=1.6 ; 95% Cl : 1.2,2.2) and cerebrovascular death (RR=2.3 ; 95% Cl : 1.4,3.8), independent of major risk factors. This association was limited to subjects with a percentage of the predicted forced expiratory volume in 1 second (FEV1% predicted) of<100%. Positive skin tests were associated with a significantly reduced cardiovascular mortality in subjects with normal lung function and weight who did not smoke (RR=0.15 ; 95% Cl : 0.05,0.46). Conversely, when subjects with positive skin tests had a body mass index of >=25 kg/m2, had an FEV1% predicted of<80%, or smoked, they had an increased risk for cardiovascular mortality. These results were not restricted to asthmatics. Our data suggest a possible link between eosinophilia and positive skin tests and cardiovascular mortality, especially in combination with other risk factors associated with its mortality. |
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