| Titre : | Risk factors for basal cell carcinoma of the skin in men : Results from the health professionals follow-up study. (1999) |
| Auteurs : | R.M. VAN DAM ; G.A. COLDITZ ; E. GIOVANNUCCI ; E.B. RIMM ; D. SPIEGELMAN ; M.A. WEINSTOCK ; W.C. Willett ; ZHIPING HUANG . (.) ; Channing Laboratory. Department of Medicine. Brigham and Women's Hospital and Harvard Medical School. Boston. MA. USA ; Department of Epidemiology. Harvard School of Public Health. Boston. MA. USA ; Department of Nutrition. Harvard School of Public Health. Boston. MA. USA |
| Type de document : | Article |
| Dans : | American journal of epidemiology (vol. 150, n° 5, 1999) |
| Pagination : | 459-468 |
| Langues: | Anglais |
| Mots-clés : | Soleil ; Exposition ; Tabagisme ; Epidémiologie ; Facteur risque ; Homme ; Etats Unis ; Amérique ; Etude prospective ; Peau [pathologie] ; Cancer ; Amérique du Nord |
| Résumé : | [BDSP. Notice produite par INIST P9O8R0xT. Diffusion soumise à autorisation]. The authors examined the relation of constitutional factors and sun exposure to risk of basal cell carcinoma of the skin (BCC) in a prospective cohort of 44,591 predominantly Caucasian US male health professionals, 40-75 years of age and free of cancer at enrollment in 1986. During 8 years of follow-up, 3,273 cases of self-reported BCC were documented. The following variables were each associated with an elevated risk of BCC : having red hair ; green, hazel, or blue eyes ; a tendency to sunburn ; and north European ancestry. The lifetime number of blistering sunburns was also positively associated with BCC risk (p trend<0.0001). Compared with men who as teenagers had been outside less than once a week, men who had been outside weekly (relative risk (RR)=1.30 ; 95% confidence interval (Cl) : 1.14,1.47) and daily (RR=1.42 ; 95% Cl : 1.24,1.63) had an elevated risk of BCC. Living in a region of residence with high solar radiation as an adult was also associated with an increased risk of BCC (RR=1.48 ; 95% Cl : 1.36,1.60), whereas living in such a region only in childhood did not increase BCC risk. These results confirm the role of constitutional factors and suggest that adult sun exposure increases BCC risk. |
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