| Titre : | Early menopause and infertility in females after treatment for childhood Cancer diagnosed in 1964-1988 in Ontario, Canada. (1999) |
| Auteurs : | A.M. CHIARELLI ; G. DARLINGTON ; L.D. MARRETT ; Department of Public Health Sciences. University of Toronto. Toronto. ON. CAN ; Division of Preventive Oncology. Cancer Care Ontario. Toronto. ON. CAN |
| Type de document : | Article |
| Dans : | American journal of epidemiology (vol. 150, n° 3, 1999) |
| Pagination : | 245-254 |
| Langues: | Anglais |
| Mots-clés : | Homme ; Femme ; Complication ; Thérapeutique ; Radiothérapie ; Thérapeutique médicamenteuse ; Médicament anticancéreux ; Canada ; Amérique ; Epidémiologie ; Amérique du Nord |
| Résumé : | [BDSP. Notice produite par INIST WDlNOR0x. Diffusion soumise à autorisation]. This study was conducted to determine the risk of menopause and infertility in female childhood cancer survivors who received abdominal-pelvic radiation and/or chemotherapy with alkylating agents in comparison with those who were treated by nonsterilizing surgery only. Females who were diagnosed in 1964-1988 before age 20 years with a histologically confirmed malignancy and who had survived for at least 5 years, had attained age 18, and were alive at time of study were identified through the Ontario Cancer Registry. Reproductive outcomes were ascertained by a telephone-administered questionnaire, and treatment data were abstracted from medical records for 830 subjects aged 18-49 years ; 719 survivors who were nonmenopausal at the end of treatment were included in the analyses. Survivors who received both alkylating agents and abdominal-pelvic radiation were more likely to be postmenopausal than were those who underwent surgery (risk ratio=2.58 ; 95% confidence interval : 1.14,5.80). Women treated with abdominal-pelvic radiation alone had a fertility deficit of 23% compared with those in the surgery group ; the deficit was restricted to women diagnosed postpuberty. Risks of menopause and infertility increased with increasing dose of abdominal-pelvic radiation and amount of alkylating agent. |
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