| Titre : | Cardiovascular status of infants and children of women infected with HIV-1 (P2C2 HIV) : a cohort study. (2002) |
| Auteurs : | Steven-E LIPSHULTZ ; Jtimothy BRICKER ; Steven-D COLAN ; Kirk-A EASLEY ; Samuel KAPLAN ; Wyman-W LAI ; Douglas-S Moodie ; Ejohn ORAV ; Mark-D SCHLUCHTER ; George SOPKO ; Thomas-J STARC ; Department of Biostatistics and Epidemiology. Division of Pediatric Cardiology. Cleveland Clinic Foundation. Cleveland. OH. USA ; Department of Cardiology. Children's Hospital. Harvard Medical School. Boston. MA. USA |
| Type de document : | Article |
| Dans : | Lancet (The) (vol. 360, n° 9330, 2002) |
| Pagination : | 368-373 |
| Langues: | Anglais |
| Mots-clés : | Sida ; Virose ; Infection ; VIH ; Rétrovirus ; Virus ; Mère ; Malformation ; Appareil circulatoire [pathologie] ; Maladie congénitale ; Epidémiologie ; Facteur risque ; Nourrisson ; Homme ; Enfant ; Immunopathologie |
| Résumé : | [BDSP. Notice produite par INIST-CNRS R0xOiAHN. Diffusion soumise à autorisation]. Background Data from cross-sectional and short-term longitudinal studies have suggested that children infected with HIV-1 might have cardiovascular abnormalities. We aimed to investigate this hypothesis in a long-term cohort study. Methods We measured cardiovascular function every 4-6 months for up to 5 years in a birth cohort of 600 infants born to women infected with HIV-1. We included 93 infants infected with HIV-1 and 463 uninfected infants (internal controls) from the same cohort. We also included a cross-sectionally measured comparison group of 195 healthy children born to mothers who were not infected with HIV-1 (external controls). Findings Children infected with HIV-1 had a significantly higher heart rate at all ages (mean difference 10 bpm, 95% Cl 8-13) than internal controls. At birth, both cohort groups of children had similar low left ventricular (LV) fractional shortening. At 8 months, fractional shortening was similar in internal and external controls, whereas in children infected with HIV-1, fractional shortening remained significantly lower than in controls for the first 20 months of life (mean difference from internal controls at 8 months 3.7%, 2.3-5.1). LV mass was similar at birth in both cohort groups, but became significantly higher in children with HIV-1 from 4-30 months (mean difference 2.4 g at 8 months, 0.9-3.9). Conclusions Vertically-transmitted HIV-1 infection is associated with persistent cardiovascular abnormalities identifiable shortly after birth. Irrespective of their HIV-1 status, infants bom to women infected with HIV-1 have significantly worse cardiac function than other infants, suggesting that the uterine environment has an important role in postnatal cardiovascular abnormalities. |
Service Documentation EHESP
Me connecter
PORTAIL DOCUMENTAIRE
École des hautes études en santé publique
Catalogue
Multi-bases
Accueil
Sélection de la langue
Adresse
Service Documentation EHESPBibliothèque Rennes Avenue du Professeur Léon Bernard – CS 74312 – 35043 Rennes Cedex Bibliothèque MSSH Paris 20 avenue George Sand - 93210 La Plaine Saint-Denis
France
Bibliothèque Rennes : 02 99 02 29 50 Bibliothèque MSSH Paris : 02 99 02 24 50
contact