| Titre : | Incidence of Creutzfeldt-Jakob disease in Switzerland. (2002) |
| Auteurs : | Markus GLATZEL ; Adriano AGUZZI ; Lorenz AMSIER ; Azra GHANI ; Colette ROGIVUE ; Johannes-R STREFFER ; Federal Office of Public Health. Division of Epidemiology and Infectious Diseases. Bern. CHE ; Institute of Neuropathology and National Reference Center for Prion Diseases. Zurich. CHE |
| Type de document : | Article |
| Dans : | Lancet (The) (vol. 360, n° 9327, 2002) |
| Pagination : | 139-141 |
| Langues: | Anglais |
| Mots-clés : | Maladie Creutzfeldt Jakob ; Infection ; Suisse ; Europe ; Homme ; Epidémiologie ; Incidence ; Examen complémentaire ; Hérédité ; Prion ; Gène ; Physiopathologie ; Système nerveux [pathologie] ; Maladie dégénérative |
| Résumé : | [BDSP. Notice produite par INIST-CNRS R0xoBnkT. Diffusion soumise à autorisation]. The Incidence of Creutzfeldt-Jakob disease (CJD) in Switzerland increased two-fold In 2001, and figures from the first quarter of 2002 indicate that it continues to rise. Neither age at onset nor duration of disease were different from previous years. Genetic analysis of the 27 reported cases revealed only one disease-associated mutation in the prion gene. None of the recognised risk factors for acquired CJD were reported on the offical notification forms. Glycotype profiling, histopathology, and immunohistochemistry indicate that none of the cases fulfilled the definition of variant CJD, which is thought to be caused by bovine prions. Several scenarios could account for the increase in CJD, including improved reporting, iatrogenic transmission, and transmission of a orion zoonosis. |
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