Chloroquine-resistant Plasmodium malariae in south... Catalogue en ligne

Titre :	Chloroquine-resistant Plasmodium malariae in south Sumatra, Indonesia. (2002)
Auteurs :	Jason-D MAGUIRE ; Jkevin BAIRD ; Michael-J BANGS ; Budhi LAKSANA ; Nurlis MAHMUD ; Sofyan MASBAR ; Purnomo PRODJODIPURO ; Priyanto SISMADI ; Iwa-W SUMAWINATA ; I.K.A. SUSANTI ; United States Naval Medical Research Unit 2. Jakarta. IDN
Type de document :	Article
Dans :	Lancet (The) (vol. 360, n° 9326, 2002)
Pagination :	58-60
Langues:	Anglais
Mots-clés :	Paludisme ; Parasitose ; Infection ; Protozoaire ; Epidémiologie ; Asie ; Homme ; Indonésie
Résumé :	[BDSP. Notice produite par INIST-CNRS mTgq3R0x. Diffusion soumise à autorisation]. Oral chloroquine is the treatment of choice for uncomplicated Plasmodium malariae infections worldwide. We did a prospective 28-day in-vivo assessment of the efficacy of chloroquine for treatment of P malarlae on Legundi Island in Lampung Bay, Sumatra, Indonesia. Of 28 patients, one had recurrent parasitaemia on day 28, and two had persistent parasitaemia to day 8. Whole-blood chloroquine and desethylchloroquine concentrations were at ordinarily effective levels (>=100 mug/L) on day 8 In both cases of persistent parasiotataemia. These findings suggest that clinical resistance to chloroquine by P malarlae occurs In the Indonesian archipelago of southeast Asia.

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