| Titre : | Adiponectin and development of type 2 diabetes in the Pima Indian population. (2002) |
| Auteurs : | Robert-S LINDSAY ; Tohru FUNAHASHI ; Robert-L HANSON ; William-C KNOWLER ; Jonathan KRAKOFF ; Yuji MATSUZAWA ; Sachiyo TANAKA ; Pantonio TATARANNI ; Department of Internal Medicine and Molecular Science. Graduate School of Medicine. Osaka University. Osaka. JPN ; National Institute of Diabetes and Digestive and Kidney Diseases. National Institutes of Health. Phoenix. AZ. USA |
| Type de document : | Article |
| Dans : | Lancet (The) (vol. 360, n° 9326, 2002) |
| Pagination : | 57-58 |
| Langues: | Anglais |
| Mots-clés : | Diabète non insulinodépendant ; Protéine ; Epidémiologie ; Homme ; Glande endocrine [pathologie] |
| Résumé : | [BDSP. Notice produite par INIST-CNRS eR0xDbE0. Diffusion soumise à autorisation]. Adiponectin Is a collagen-like circulating protein secreted by adipocytes that Is proposed to mediate obesity-related resistance to Insulin. In a case-control series, we assessed the role of adiponectin In later development of type 2 diabetes In 70 patients who later developed type 2 diabetes and 70 controls, matched for body-mass Index, age, and sex. Cases and controls were taken from the longitudinal study of health In the Pima Indian population. At baseline, the concentration of adiponectin was lower In cases than In controls (p=0.01) and Individuals with high concentrations of this protein were less likely to develop type 2 diabetes than those with low concentrations (Incidence rate ratio 0.63 [95% CI 0.43-0.92] ; p=0-02). |
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