Résumé :
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[BDSP. Notice produite par INIST-CNRS R0xxb5HH. Diffusion soumise à autorisation]. Objectives. This research assessed the relationship between the deliveries of carcinogenic tobacco-specific nitrosamines (TSNAs) and the Federal Trade Commission (FTC) "tar" ratings of US commercial cigarettes. Methods. Analysis of covariance (ANCOVA) was used to assess the explanatory power of FTC tar, the particular manufacturer, and other cigarette characteristics to predict the yields of four TSNAs (N'-nitrosonornicotine [NNN], 4- (N-methyl-N-nitrosamino) - 1- (3-pyridyl) - 1 - butanone [NNK], N'-nitrosoanatabine [NAT], and N'-nitrosoanabasine [NAB]) in 26 US commercial brands tested in the 1999 Massachusetts Benchmark Study. Results. When FTC tar alone was used to predict TSNA yield, the squared correlation coefficient (R2) was only 38% for NNN, 76% for NNK, 46% for NAT, and 49% for NAB. Inclusion of manufacturer-specific variables significantly (p
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