| Titre : | Serum IgG antibodies to human herpesvirus-6 (HHV-6) do not predict the progression of HIV disease to AIDS. (1999) |
| Auteurs : | M. DORRUCCI ; M.B. ALLIEGRO ; M. ANDREONI ; M. BARBANERA ; F. CASTELLI ; V. COLANGELI ; G. MAZZARELLO ; E. NICASTRI ; L. ORTONA ; P. PEZZOTTI ; R. PRISTERA ; G. REZZA ; B. SALASSA ; G. TARANTINI ; M.A. URSITTI ; L. VENTURA ; M. ZIGNANI ; Centro Operativo Aids. Istituto Superiore di Sanità. Rome. ITA ; Infectious Diseases. University of Tor Vergata. Rome. ITA ; Italian Seroconversion Study group. ITA |
| Type de document : | Article |
| Dans : | European journal of epidemiology (vol. 15, n° 4, 1999) |
| Pagination : | 317-322 |
| Langues: | Anglais |
| Mots-clés : | Sida ; Virose ; Infection ; Virus ; Anticorps ; Plasma sanguin ; Epidémiologie ; Taux ; Evolution ; Pronostic ; Homme ; Italie ; Europe ; Immunopathologie |
| Résumé : | [BDSP. Notice produite par INIST 4HtsR0xm. Diffusion soumise à autorisation]. Objectives : To evaluate if different levels of human herpesvirus 6 (HHV-6) antibodies can predict HIV disease progression. Design : Longitudinal study of individuals with a documented date of HIV seroconversion. Setting : Clinical centers located throughout Italy. Patients : Individuals who serconverted for HIV between 1983 and 1995 in Italy. Methods : Sera were tested for IgG antibodies to HHV-6 using a commercial enzyme immunoassay. A serum sample with an optical density (OD) >=242 (i.e. the mean value of 10 negative controls+4 x standard deviation) was considered as HHV-6 positive ; the progression of HIV disease was evaluated estimating the relative hazards (RH) of AIDS (by Cox models) for individuals with higher levels vs. lower levels of HHV-6 antibodies or considering levels of antibodies based on 10% increase of the distribution (deciles). Rates of CD4 decline fitting linear regression were also estimated. Results : A total of 381 persons were followed for a median time of 4 years (range : 0.15-9 years) following the date of collection of the serum sample. The median OD value of HHV-6 antibodies was 306, with an interquartile range of 241-440 and a range of 48-2330. A slight inverse correlation was found between HHV-6 antibody levels and age of the individual at the time of serum collection (Spearman rank correlation coefficient, - 0.16 ; p=0.0013). (...) |
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