Titre :
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Mother-to-child transmission of hepatitis C virus : evidence for preventable peripartum transmission. (2000)
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Auteurs :
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D.M. GIBB ;
K. BUTLER ;
M. CAFFERKEY ;
D.T. DUNN ;
R.L. GOODALL ;
M. HEALY ;
P. NEAVE ;
Institute of Child Health. London. GBR ;
Medical Research Council Clinical Trials Unit. London. GBR ;
Our Lady's Hospital for Sick Children and Children's Hospital. Dublin. IRL
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Type de document :
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Article
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Dans :
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Lancet (The) (vol. 356, n° 9233, 2000)
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Pagination :
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904-907
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Langues:
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Anglais
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Mots-clés :
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Virus
;
Prévention santé
;
Royaume Uni
;
Europe
;
Femme
;
Homme
;
Virose
;
Infection
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Résumé :
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[BDSP. Notice produite par INIST fgjyVR0x. Diffusion soumise à autorisation]. Background Little information is available about the timing of mother-to-child transmission of hepatitis C virus (HCV), and no interventions to decrease transmission rates have been identified. We examined the effect of risk factors, including mode of delivery, on the vertical transmission rate. Methods Data from HCV-infected women and their infants from three hospitals in Ireland and from a British Paediatric Surveillance Unit study of infants born to HCV-infected mothers were used to estimate the vertical transmission rate and risk factors for transmission. We used a probabilistic model using methods that simultaneously estimated the time to HCV-antibody loss in uninfected infants and the diagnostic accuracy of PCR tests for HCV RNA. Findings 441 mother-child pairs from the UK (227) and Ireland (214) were included. 50% of uninfected children became HCV-antibody negative by 8 months and 95% by 13 months. The estimated specificity of PCR for HCV RNA was 97% (95% CI 96-99) and was unrelated to age ; sensitivity was only 22% (7-46) in the first month but rose sharply to 97% (85-100) thereafter. The vertical transmission rate was 6.7% (4.1-10.2) overall, and 3.8 times higher in HIV coinfected (n=22) than in HIV-negative women after adjustment for other factors (p=0.06). No effect of breastfeeding on transmission was observed, although only 59 women breastfed. (...)
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