Résumé :
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[BDSP. Notice produite par INIST fCCXR0xR. Diffusion soumise à autorisation]. Objectives. This study examined the association between intake of whole vs refined grain and the risk of type 2 diabetes mellitus. Methods. We used a food frequency questionnaire for repeated dietary assessments to prospectively evaluate the relation between whole-grain intake and the risk of diabetes mellitus in a cohort of 75 521 women aged 38 to 63 years without a previous diagnosis of diabetes or cardiovascular disease in 1984. Results. During the 10-year follow-up, we confirmed 1879 incident cases of diabetes mellitus. When the highest and the lowest quintiles of intake were compared, the age and energy-adjusted relative risks were 0.62 (95% confidence interval [Cl]=0.53,0.71, P trend<. 0001) for whole grain, 1.31 (95% Cl=1.12,1.53, P trend=0003) for refined grain, and 1.57 (95% Cl=1.36,1.82, P trend<. 0001) for the ratio of refined-to whole-grain intake. These findings remained significant in multivariate analyses. The findings were most evident for women with a body mass index greater than 25 and were not entirely explained by dietary fiber, magnesium, and vitamin E. Conclusions. These findings suggest that substituting whole-for refined-grain products may decrease the risk of diabetes mellitus.
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