| Titre : | Relationship of baseline serum cholesterol levels in 3 large cohorts of younger men to long-term coronary, cardiovascular, and all-cause mortality and to longevity. (2000) |
| Auteurs : | J. STAMLER ; M.L. DAVIGLUS ; A.R. DYER ; D.B. GARSIDE ; P. GREENLAND ; I.D. NEATON ; Department of Preventive Medicine. Northwestern University Medical School. Chicago. IL. USA |
| Type de document : | Article |
| Dans : | JAMA - Journal of the american medical association (vol. 284, n° 3, 2000) |
| Pagination : | 311-318 |
| Langues: | Anglais |
| Mots-clés : | Cardiopathie coronaire ; Mortalité ; Longévité ; Examen complémentaire ; Facteur risque ; Epidémiologie ; Tabagisme ; Pression artérielle ; Appareil circulatoire [pathologie] ; Adulte ; Homme ; Etats Unis ; Amérique ; Lipide ; Métabolisme [pathologie] ; Appareil respiratoire [pathologie] ; Amérique du Nord |
| Résumé : | [BDSP. Notice produite par INIST t89gR0xJ. Diffusion soumise à autorisation]. Context Based on observational and interventional data for middle-aged cohorts (agec 40-64 years), serum cholesterol level is known to be an established major risk factor fo coronary heart disease (CHD). However, findings for younger people are limited, anc the value of detecting and treating hypercholesterolemia in younger adults is debated. Objective2 : 1 To evaluate the long-term impact of unfavorable serum cholesterol levels on risk of death from CHD, cardiovascular disease (CVD), and all causes. Design, Setting, and Participants Three prospective studies, from which were selected 3 cohorts of younger men with baseline serum cholesterol level measurements anc no history of diabetes mellitus or myocardial infarction. A total of 11017 men aged 18 through 39 years screened in 1967-1973 for the Chicago Heart Association Detectior Project in Industry (CHA) ; 1266 men aged 25 through 39 years examined in 1959-1963 in the Peoples Gas Company Study (PG) ; and 69205 men aged 35 through 39 years screened in 1973-1975 for the Multiple Risk Factor Intervention Trial (MRFIT). Main Outcome Measures Cause-specific mortality during 25 (CHA), 34 (PG), and 16 (MRFIT) years of follow-up ; mortality risks ; and estimated life expectancy in rela tion to baseline serum cholesterol levels. (...) |
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