| Titre : | Risk of infection with Mycobacterium tuberculosis in travellers to areas of high tuberculosis endemicity. (2000) |
| Auteurs : | F.G.J. COBELENS ; I.W.E. DRAAYER-JANSEN ; M.E.A. MENSEN ; Achm SCHEPP-BEELEN ; H. VAN DEUTEKOM ; Pjhj VAN GERVEN ; R.P.M. VAN KESSEL ; Department of Tuberculosis Control. Municipal Health Service. Amsterdam. USA |
| Type de document : | Article |
| Dans : | Lancet (The) (vol. 356, n° 9228, 2000) |
| Pagination : | 461-465 |
| Langues: | Anglais |
| Mots-clés : | Bactérie ; Infection ; Voyage ; Endémie ; Incidence ; Facteur risque ; Epidémiologie ; Europe ; Adulte ; Homme ; Pays Bas |
| Résumé : | [BDSP. Notice produite par INIST R0x8Bywe. Diffusion soumise à autorisation]. Background No data exist on risks of infection with Mycobacterium tuberculosis in travellers. We studied incidences of and risk factors for tuberculin skin-test conversion among Dutch long-term travellers to countries of high tuberculosis endemicity. Methods In a multicentre, prospective cohort study based in travel and tuberculosis clinics in the Netherlands, 1072 BCG-naive immunocompetent travellers to countries with an estimated annual risk of M tuberculosis infection of at least 1% were skin tested before departure with 1 tuberculin unit purified protein derivative (PPD) of M tuberculosis in Tween-80. Those with results less than 2 mm were retested 2-4 months after their return with simultaneous testing for cross-sensitivity to environmental mycobacteria (1 tuberculin unit PPD of M scrofulaceum in Tween-80). M tuberculosis infection was defined as a post-travel M tuberculosis tuberculin skin-test result of at least 10 mm that was 3 mm or more larger than the M scrofulaceum result. Findings Post-travel skin-test results were available for 656 (66%) of 988 individuals who were eligible for follow-up. Among these, 12 M tuberculosis infections were identified (1.8%). The overall incidence rate was 3.5 per 1000 person-months of travel (95% Cl 2.0-6.2), and 2.8 per 1000 person-months of travel (1.2-5.5) after exclusion of health-care workers. Two had active tuberculosis at the time of testing (incidence rate 0.6 per 1000 person-months of travel [0.3-2.3]). (...) |
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