Titre : | Incidence of childhood precursor B-cell acute lymphoblastic leukaemia in north-west England. (2000) |
Auteurs : | R.J.Q. MCNALLY ; J.M. BIRCH ; O.B. EDEN ; G.M. TAYLOR ; Crc Paediatric and Famillal Cancer Research Group. Royal Manchester Children's Hospital. Manchester. GBR |
Type de document : | Article |
Dans : | Lancet (The) (vol. 356, n° 9228, 2000) |
Pagination : | 485-486 |
Langues: | Anglais |
Mots-clés : | Incidence ; Sexe ; Epidémiologie ; Royaume Uni ; Europe ; Enfant ; Homme ; Préadolescent |
Résumé : | [BDSP. Notice produite par INIST R0xAeq5W. Diffusion soumise à autorisation]. A temporal Increase In the Incidence of childhood acute lymphoblastic leukaemia (ALL) In the UK has been noted. We present data from the Manchester Children's Tumour Registry which provide strong evidence that the Increase Is a result of an Increase In the precursor B-cell subtype. In the childhood peak (age 1-4 years), the annual Increase In precursor B-cell ALL between 1980 and 1998 was 3.0% (p=0.024). Recent findings are consistent with the causal Involvement of infections in precursor B-cell ALL. |