| Titre : | Inverse association of physical fitness with plasma fibrinogen level in children : The Columbia University BioMarkers study. (2000) |
| Auteurs : | C.R. ISASI ; L. BERGLUND ; R. DECKELBAUM ; S. SHEA ; T.J. STARC ; R.P. TRACY ; Division of General Medicine. Department of Medicine. Columbia University College of Physicians and Surgeons. New York. NY. USA |
| Type de document : | Article |
| Dans : | American journal of epidemiology (vol. 152, n° 3, 2000) |
| Pagination : | 212-218 |
| Langues: | Anglais |
| Mots-clés : | Facteur risque ; Appareil circulatoire [pathologie] ; Plasma sanguin ; Enfant ; Homme ; Activité physique |
| Résumé : | [BDSP. Notice produite par INIST v7H9R0xM. Diffusion soumise à autorisation]. Plasma fibrinogen has emerged as a risk factor for cardiovascular disease in adults, but relatively little is known about the correlates of plasma fibrinogen level in childhood. In the Columbia University BioMarkers Study (1994-1998), the authors evaluated the association between physical fitness and plasma fibrinogen level in 193 children 4-25 years old ; 68% were Hispanic and 46% male. Fitness level assessed by treadmill testing was inversely associated with plasma fibrinogen (r=-0.24, p<0.001). Plasma fibrinogen levels showed a graded inverse relation with tertiles of fitness assessed by treadmill (p<0.001). In multivariate analyses, after adjustment for age, sex, race/ethnicity, body mass index, and presence of the A allele in the - 455 position of the bêta-fibrinogen promoter gene, the fitness level remained inversely associated with plasma fibrinogen level (bêta=-1.3,95% confidence interval (Cl) : - 2.3, - 0.34). Resting heart rate was also correlated with plasma fibrinogen level (r=0.18, p<0.05). Fibrinogen levels (mg/dl) increased over tertiles of resting heart rate (p=0.002) and were significantly associated with resting heart rate in multivariate analysis (bêta=0.82,95% Cl : 0.17,1.5). These findings indicate that plasma fibrinogen is inversely associated with physical fitness in children independent of body mass index. |
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