| Titre : | Special issue on environmental epidemiology. Measurement of low levels of arsenic exposure : A comparison of water and toenail concentrations. (2000) |
| Auteurs : | M.R. KARAGAS ; J. BLUM ; B. KLAUE ; J.S. MORRIS ; V. SPATE ; V. STANNARD ; T.D. TOSTESON ; J.E. Weiss ; Department of Earth Sciences. Dartmouth College. Hanover. NH. USA ; Departments of Community and Family Medicine. Dartmouth Medical School. Hanover. NH. USA ; Research Reactor Center. University of Missouri. Columbia. MO. USA |
| Type de document : | Article |
| Dans : | American journal of epidemiology (vol. 152, n° 1, 2000) |
| Pagination : | 84-90 |
| Langues: | Anglais |
| Mots-clés : | Exposition ; Taux ; Eau [boisson] ; Ongle ; Epidémiologie ; Homme ; Etats Unis ; Amérique ; Amérique du Nord |
| Résumé : | [BDSP. Notice produite par INIST R0xaZ3BB. Diffusion soumise à autorisation]. A study was conducted to evaluate toenail arsenic concentrations as a biologic marker of drinking water arsenic exposure. Study subjects were controls in a US population-based case-control study of nonmelanoma skin cancer, randomly selected from drivers'license records (those<65 years of age) and Medicare enrollment files (those >=65 years of age). Between 1994 and 1997, a total of 540 controls were interviewed and toenail samples of sufficient weight were collected from 506 (93.7%) of these. Beginning in 1995, a sample of tap water was taken from the participants'homes ; a total of 217 (98.6%) water samples were obtained from the 220 subjects interviewed. Arsenic determinations were made from toenail samples using neutron activation analysis. Water samples were analyzed using hydride-generation magnet sector inductively coupled mass spectrometry. Among 208 subjects with both toenail and water measurements, the correlation (r) between water and nail arsenic was 0.65 (p<0.001) among those with water arsenic concentrations of 1 mug/liter or higher and 0.08 (p=0.31) among those with concentrations below 1 mug/liter (overall r=0.46, p<0.001). Our data suggest that toenail samples provide a useful biologic marker for quantifying low-level arsenic exposure. |
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