Titre :
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Secular trends in the survival of HIV-infected homosexual men in Amsterdam and Vancouver estimated from a death-included CD4-staged Markov model. (2000)
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Auteurs :
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J.C.M. HENDRIKS ;
R.A. COUTINHO ;
K.J.P. CRAIB ;
M.T. SCHECHTER ;
H.A.M. VAN DRUTEN ;
G.J.P. VAN GRIENSVEN ;
P.J. VEUGELERS ;
Department of Medical Statistics. University of Nijmegen. NLD ;
Department of Public Health. Municipal Health Service. Amsterdam. NLD
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Type de document :
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Article
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Dans :
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International journal of epidemiology (vol. 29, n° 3, 2000)
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Pagination :
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565-572
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Langues:
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Anglais
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Mots-clés :
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Sida
;
Virose
;
Infection
;
VIH
;
Rétrovirus
;
Virus
;
Survie
;
Homme
;
Homosexualité
;
Evolution
;
Immunopathologie
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Résumé :
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[BDSP. Notice produite par INIST 4n8R0xx6. Diffusion soumise à autorisation]. Background The purpose of this study was to investigate secular trends in waiting times in CD4-based stages of human immunodeficiency virus (HIV) disease progression in two cohorts of homosexual men, one in Vancouver and one in Amsterdam. All HIV-positive men with two or more CD4 counts in their AIDS-free period between 1 January 1985 and 1 January 1997 were included in this study. Data regarding clinical AIDS diagnoses (using the 1987 Centers for Disease Control and Prevention [CDC] AIDS case definition) and death were collected through active follow-up, review of hospital records, and municipal/national registries. The Vancouver Lymphadenopathy-AIDS Study (VLAS), was started in November 1982 and had enrolment until December 1984. Both HIV-negative and HIV-positive men were followed at intervals of 3-6 months until 1986 and annually thereafter. The Amsterdam cohort study on HIV and AIDS (ACS) started in December 1984, has ongoing enrolment and follow-up of both HIV-negative and HIV-positive homosexual men. The HIV-positive men were followed at intervals of 3 months. Methods The CD4-based stage of an individual at each visit was determined using smoothed data. For each cohort and in each calendar time period, a CD4-based Markov model with death as the absorbing stage was fitted to the data. The parameters in this model were estimated using the method of maximum likelihood and confidence intervals were calculated using bootstrap methods. (...)
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