| Titre : | Can statin therapy reduce the risk of melanoma ? A meta-analysis of randomized controlled trials. (2010) |
| Auteurs : | Stefanos BONOVAS ; BAGOS (Pantelis) : GRC. Department of Biomedical Informatics. University of Central Greece. Lamia. ; Kalitsa Filioussi ; Georgios NIKOLOPOULOS ; PEPONI (Evangelia) : CHE. Department of Radiation Oncology. University Hospital of Zurich. Zurich. ; SITARAS (Nikolaos-M) : GRC. Department of Pharmacology. School of Medicine. University of Athens. Athens. ; Center for Diseases Control and Prevention. Athens. GRC |
| Type de document : | Article |
| Dans : | European journal of epidemiology (vol. 25, n° 1, Janvier 2010) |
| Pagination : | 29-35 |
| Langues: | Anglais |
| Mots-clés : | Thérapeutique ; Facteur risque ; Risque ; Randomisation ; Essai préventif ; Essai thérapeutique ; Prévention santé ; Chimioprophylaxie ; Homme ; Epidémiologie ; Enzyme ; Cancer |
| Résumé : | [BDSP. Notice produite par INIST-CNRS loR0xAH9. Diffusion soumise à autorisation]. A growing body of literature suggests that statins may have a chemopreventive potential against melanoma through pleiotropic anti-inflammatory, immunomodulatory, and antiangiogenesis mechanisms. Our aim was to examine this association through a detailed meta-analysis of randomized controlled trials (RCTs). A comprehensive search for trials published up to June 2009 was performed, reviews of each study were conducted and data were abstracted. Prior to meta-analysis, the studies were evaluated for publication bias and heterogeneity. Pooled relative risk estimates (RR) and 95% confidence intervals (CIs) were calculated using the fixed-and the random-effects models. Subgroup and sensitivity analyses were also conducted. Sixteen RCTs of statins for cardiovascular outcomes, involving 62,568 individuals with a mean age of 60 years and an average follow-up of nearly 4.7 years, contributed to the analysis. We found no evidence of publication bias (P=0.47) or heterogeneity among the studies (P=0.25). Statin use did not significantly affect the risk of developing melanoma assuming either a fixed- (RR=0.92,95% CI : 0.67-1.26), or a random-effects model (RR=0.92,95% CI : 0.62-1.36). This neutral effect was further supported by the results of subgroup and sensitivity analyses. Our findings do not support a protective effect of statins against melanoma. |
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