Résumé :
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[BDSP. Notice produite par INIST-CNRS R0xB77kl. Diffusion soumise à autorisation]. Background : The association between extremes of relative body weight and mortality has not been well characterized in developing countries. A prospective cohort study was conducted in Mumbai (India) to study the association of relative body weight, as estimated by body mass index [BMI=weight (kg)/height2 (m2) ], with mortality. Methods : Using the voters'list as the selection frame, 148173 men and women aged>=35 years were recruited during 1991-97 in Mumbai city and were followed-up during 1997-2003. Results : During 774129 person-years of follow-up, 13261 deaths were observed. After adjusting for the potential confounders, increased mortality was observed in all under-weight categories [relative risk (RR)=1.94 for BMI<16. okg/m2,1.38 for BMI 16.0 to<17.0 and 1.24 for BMI 17.0 to<18.5 among women ; the corresponding values for men were 2.24,1.45 and 1.27, respectively] when compared with the rate in the normal weight category (BMI 18.5 to<25.0). Extremely thin (BMI<16.0 kg/m2) cohort members were at highest risk for death due to tuberculosis (TB) (RR=7.20 and 14.94 in women and men, respectively), cancer (RR=1.87 and 2.44, respectively) and respiratory diseases (RR=3.46 and 4.35, respectively). Subjects with above normal BMI had lower mortality risk than those with normal BMI values. Over-weight (BMI 25.0 to<30.0) women (RR=0.89) and men (RR=0.87) were at a lower risk ; however, obese (BMI>=30.0) men<60 years of age had an increased mortality risk (RR=1.22). Conclusion : In Mumbai, under-weight was associated with an increased risk of pre-mature death. Despite the growing concerns regarding the gradual transition toward increasing rates of obesity, under-nutrition remains a major health problem in India. This study suggests the need for public health policies focusing on reducing under-nutrition.
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