| Titre : | Smoking as a risk factor for dementia and cognitive decline : A meta-analysis of prospective studies. (2007) |
| Auteurs : | Kaarin-J ANSTEY ; O'KEARNEY (Richard) : AUS. School of Psychology. The Australian National University. Canberra. ; Agus SALIM ; Chwee VON SANDEN |
| Type de document : | Article |
| Dans : | American journal of epidemiology (vol. 166, n° 4, 2007) |
| Pagination : | 367-378 |
| Langues: | Anglais |
| Mots-clés : | Tabagisme ; Démence Alzheimer ; Tabac ; Facteur risque ; Etude prospective ; Fonction cognitive ; Vaisseau ; Epidémiologie ; Homme ; Maladie dégénérative ; Système nerveux [pathologie] ; Appareil cardiovasculaire |
| Résumé : | [BDSP. Notice produite par INIST-CNRS 0R0x2Hek. Diffusion soumise à autorisation]. The authors assessed the association of smoking with dementia and cognitive decline in a meta-analysis of 19 prospective studies with at least 12 months of follow-up. Studies included a total of 26,374 participants followed for dementia for 2-30 years and 17,023 participants followed up for 2-7 years to assess cognitive decline. Mean study age was 74 years. Current smokers at baseline, relative to never smokers, had risks of 1.79 (95% confidence interval (Cl) : 1.43,2.23) for incident Alzheimer's disease, 1.78 (95% Cl : 1.28,2.47) for incident vascular dementia, and 1.27 (95% Cl : 1.02,1.60) for any dementia. Compared with those who never smoked, current smokers at baseline also showed greater yearly declines in Mini-Mental State Examination scores over the follow-up period (effect size (bêta)=-0.13,95% Cl : - 0.18, - 0.08). Compared with former smokers, current smokers at baseline showed an increased risk of Alzheimer's disease (relative risk=1.70,95% Cl : 1.25,2.31) and an increased decline in cognitive abilities (effect size (bêta)=-0.07,95% Cl : - 0.11, - 0.03), but the groups were not different regarding risk of vascular dementia or any dementia. The authors concluded that elderly smokers have increased risks of dementia and cognitive decline. |
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