| Titre : | Hepatitis C virus infection and the development of type 2 diabetes in a community-based longitudinal study. (2007) |
| Auteurs : | WANGL (Chong-Shan) : TWN. A-Lein Community Health Center. Kaohsiung County. ; CHANG (Ting-Tsung) : TWN. Division of Gastroenterology. Department of Internal Medicine and Institute of Clinical Medicine. College of Medicine. National Cheng Kung University. Tainan. ; Pesus CHOU ; WANG (Shan-Tair) : TWN. Institute of Public Health. College of Medicine. National Cheng Kung University. Tainan. ; YAO (Wei-Jen) : TWN. Department of Radiology. College of Medicine. National Cheng Kung University. Tainan. ; National Yang-Ming University. Institute of Public Health. Community Medicine Research Center. Taipei. TWN |
| Type de document : | Article |
| Dans : | American journal of epidemiology (vol. 166, n° 2, 2007) |
| Pagination : | 196-203 |
| Langues: | Anglais |
| Mots-clés : | Hépatite virale C ; Communauté ; Epidémiologie ; Homme ; Virose ; Infection ; Appareil digestif [pathologie] ; Foie [pathologie] ; Glande endocrine [pathologie] ; Métabolisme [pathologie] |
| Résumé : | [BDSP. Notice produite par INIST-CNRS 671R0xWW. Diffusion soumise à autorisation]. The temporal relation of hepatitis C virus (HCV) infection to the development of type 2 diabetes remains unknown. The authors followed 4,958 persons aged>40 years without diabetes (3,486 seronegative, 812 anti-HCV+116 with hepatitis B virus/HCV coinfection, and 544 hepatitis B surface antigen (HBsAg)+) from a community-wide cohort in southern Taiwan for 7 years (1997-2003) to study the risk of diabetes associated with HCV infection. A total of 474 participants developed diabetes. The 7-year cumulative incidence was 7.5% for HBsAg+8.6% for seronegative, 14.3% for anti-HCV+and 14.7% for coinfected participants. Compared with HCV-persons, HCV+persons had a higher cumulative incidence of diabetes (log-rank test, p<0.0001). A multivariate Cox proportional hazards model showed that anti-HCV+ (hazard ratio=1.7,95% confidence interval : 1.3,2.1), coinfection (hazard ratio=1.7), overweight, obesity, and increasing age were significantly associated with diabetes (p<0.05). Gender, educational level, HBsAg+status, alcohol consumption, and smoking were not significant. After stratification by age and body mass index, the risk ratio for diabetes in anti-HCV+participants increased when age decreased and body mass index levels increased (p<0.001). Results show that HCV infection is an independent predictor of diabetes, especially for anti-HCV+persons who are younger or have a higher body mass index. |
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