| Titre : | Fetal growth and acute childhood leukemia : Looking beyond birth weight. (2007) |
| Auteurs : | Elizabeth MILNE ; Eve BLAIR ; Carol BOWER ; Nicholas DE KLERK ; Crystal-L LAURVICK ; University of Western Australia. Centre for Child Health Research. Telethon Institute for Child Health Research. Perth Western Australia. AUS |
| Type de document : | Article |
| Dans : | American journal of epidemiology (vol. 166, n° 2, 2007) |
| Pagination : | 151-159 |
| Langues: | Anglais |
| Mots-clés : | Enfant ; Poids naissance ; Dossier médical ; Modèle ; Facteur risque ; Epidémiologie ; Homme |
| Résumé : | [BDSP. Notice produite par INIST-CNRS s7R0xRK5. Diffusion soumise à autorisation]. The authors examined the relation between birth weight, intrauterine growth, and risk of childhood leukemia using population-based linked health data from Western Australia. A cohort of 576,593 infants born in 1980-2004 were followed from birth to diagnosis of acute lymphoblastic leukemia (ALL) (n=243) or acute myeloid leukemia (AML) (n=36) before their 15th birthday, death, or the end of follow-up (December 31,2005). Data were analyzed using Cox regression. Risk of ALL was positively associated with the proportion of optimal birth weight-a measure of the appropriateness of fetal growth-particularly among children younger than 5 years ; the hazard ratio for a 1 - standard-deviation increase in proportion of optimal birth weight was 1.25 (95% confidence interval : 1.07,1.47). Among children younger than 5 years not classified as having high birth weight (defined as>3,500 g,>3,800 g, and>4,000 g), a 1-unit increase in proportion of optimal birth weight was associated with an approximately 40% increase in ALL risk. This suggests that accelerated growth, rather than high birth weight per se, is involved in the etiology of ALL. These findings are consistent with a role for insulin-like growth factor I in the causal pathway. Findings for AML were inconclusive, probably because of small numbers. |
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