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Is low folate a risk factor for depression ? A meta-analysis and exploration of heterogeneity.

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Titre :	Is low folate a risk factor for depression ? A meta-analysis and exploration of heterogeneity. (2007)
Auteurs :	Simon GILBODY ; LIGHTFOOT (Tracy) : GBR. Epidemiology and Genetic Unit. Department of Health Sciences. University of York. York. ; Trevor SHELDON ; University of York. Department of Health Sciences. York. GBR
Type de document :	Article
Dans :	Journal of epidemiology and community health (vol. 61, n° 7, 2007)
Pagination :	631-637
Langues:	Anglais
Mots-clés :	Folate ; Vitamine ; Etat dépressif ; Facteur risque ; Examen complémentaire ; Trouble humeur
Résumé :	[BDSP. Notice produite par INIST-CNRS R0xT1ut2. Diffusion soumise à autorisation]. Low folate has been causatively linked to depression, but research is contradictory. An association may arise due to chance, bias, confounding or reverse causality. A systematic review of observational studies which examined the association between depression and folate was conducted. 11 relevant studies (15 315 participants ; three case-control studies, seven population surveys and one cohort study) examining the risk of depression in the presence of low folate were found. Pooling showed a significant relationship between folate status and depression (odds ratio (OR) pooled unadjusted=1-55 ; 95% Cl 1.26 to 1.91). This relationship remained after adjustment for potential confounding (OR) pooled adjusted=1.42 ; 95% Cl 1.10 to 1.83). Folate levels were also lower in depression. There is accumulating evidence that low folate status is associated with depression. Much of this evidence comes from case-control and cross-sectional studies. Cohort studies and definitive randomised-controlled trials to test the therapeutic benefit of folate are required to confirm or refute a causal relationship.