| Titre : | Effect of age, sex and smoking habits on pneumococcal antibodies in an elderly population. (1997) |
| Auteurs : | U. SANKILAMPI ; A. BLOIGU ; R. ISOAHO ; S.L. KIVELA ; M. LEINONEN ; National Public Health Institute. Department in Oulu. Oulu. FIN |
| Type de document : | Article |
| Dans : | International journal of epidemiology (vol. 26, n° 2, 1997) |
| Pagination : | 420-427 |
| Langues: | Anglais |
| Mots-clés : | Bactérie ; Anticorps ; Age ; Sexe ; Tabagisme ; Epidémiologie ; Prévalence ; Personne âgée ; Homme ; Finlande ; Europe ; Appareil respiratoire [pathologie] ; Infection |
| Résumé : | [BDSP. Notice produite par INIST UR0x2Ave. Diffusion soumise à autorisation]. Background. Pneumococcal infections are a common cause of morbidity and mortality among elderly people. Protection against pneumococcal infections is mediated by serotype-specific antibodies to capsular polysaccharides. To obtain an estimate of anti-pneumococcal immunity, prevalence and levels of pneumococcal antibodies were studied in an unvaccinated elderly population. Methods. IgG antibodies to pneumococcal serotypes 3,6A, and 8 and to cell wall polysaccharide (C-PS, a common antigen to all pneumococci) were measured by enzyme immuno-assay in 480 subjects aged 64-97 years (206 men, 274 women) who were a random sample (41%) of elderly inhabitants in a semirural community in Finland. Results. An average of 10% of the elderly lacked antibodies to serotypes 3,6A, and 8, and 62% of the elderly had them in low titres only. Anti-C-PS antibodies were found in 99% of the elderly, and in significantly higher titres than anti-capsular antibodies. Antibody titres to C-PS and to type 6A decreased with age. Elderly women had significantly lower antibody levels than men. Among the men, current smokers had higher antibody titres than non-smokers ; in the women, this analysis was not possible because of infrequent history of smoking. The effect of smoking on antibody titres was reversible after cessation of smoking. Conclusions. A considerable proportion of the elderly lacked protective antibodies to commonly infecting pneumococcal serotypes 3,6A, and 8. (...) |
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